Evaluating genetic factors in preventing dental caries
Evaluation of Caries Prevention Based on Genetic Etiology and Risk: Protocol for a Multicenter Randomized Controlled and Adaptive Trial for Oral Personalized Care (PRECARIES)
This study is testing if understanding genetic factors can help prevent cavities in teens getting braces by comparing new prevention methods to standard care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 520 (estimated) |
| Ages | 13 Years to 23 Years |
| Sex | All |
| Sponsor | Umeå University Academic / other |
| Locations | 1 site (Umeå) |
| Trial ID | NCT05600517 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the prevention of dental caries by assessing genetic risk factors and saliva immunodeficiency in adolescents undergoing orthodontic treatment. A total of 2000 adolescents will be screened, with 520 selected for a randomized controlled trial comparing intensive prevention strategies against traditional methods. Participants will be genotyped to categorize them into susceptible and non-susceptible groups, and clinical outcomes will be measured at multiple time points using various diagnostic techniques. The study aims to develop personalized oral care strategies based on genetic predisposition.
Who should consider this trial
Good fit: Ideal candidates are adolescents undergoing orthodontic treatment with fixed multibrackets appliances.
Not a fit: Patients with impacted canines, agenesis in the frontal region, or those who have undergone maxillofacial surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective, personalized prevention strategies for dental caries in adolescents.
How similar studies have performed: Other studies have shown promise in using genetic factors for personalized medicine, but this specific approach to caries prevention is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - undergoing orthodontic treatment with fixed multibrackets appliance in the upper and lower arch Exclusion Criteria: * impacted canines * agenesis in the frontal region * maxillofacial surgery
Where this trial is running
Umeå
- Umeå University Hospital — Umeå, Sweden (Recruiting)
Study contacts
- Principal investigator: Nicklas Stromberg, Prof — Umeå University
- Study coordinator: Nicklas Strömberg, Prof
- Email: nicklas.stromberg@umu.se
- Phone: +46733544395
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.