Evaluating fluid resuscitation effects on capillary refill time and organ function in septic shock patients
Effects of Fluid Resuscitation on Capillary Refilling Time and Organ Functions in Septic Shock
This study is testing how giving fluids to patients with septic shock affects their capillary refill time and organ function to see if it helps them get better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Samsun University Academic / other |
| Locations | 1 site (Samsun, Ilkadim) |
| Trial ID | NCT06067516 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess how fluid resuscitation impacts capillary refill time and organ perfusion in patients diagnosed with sepsis or septic shock. By measuring changes in capillary refill time and correlating them with the Sequential Organ Failure Assessment (SOFA) score, the study seeks to understand the relationship between microcirculation and organ function. Patients will be monitored in the intensive care unit, and various clinical parameters will be collected to evaluate the effectiveness of fluid resuscitation. The findings could provide insights into optimizing treatment strategies for septic shock.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who are admitted to intensive care with a diagnosis of sepsis or septic shock.
Not a fit: Patients with known heart, kidney, or liver failure, or those whose shock is due to neurogenic, cardiogenic, or obstructive causes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for septic shock, potentially enhancing patient survival rates.
How similar studies have performed: Previous studies have indicated that capillary refill time is a valuable indicator of disease severity in septic shock, suggesting that this approach may yield meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Over 18 years old * Admitted to intensive care with a diagnosis of sepsis or septic shock * Systolic blood pressure \< 90 mmHg or Mean blood pressure \< 65 mmHg * Those who need vasopressor medication * Urine output \< 0.5 ml/kg/h for at least two hours * Tachycardia (Heart rate \> 100/min) * Serum Lactate \> 2 mmol/L * Patients with central venous oxygen saturation (ScvO) \< 70% Exclusion Criteria * Not approved by the patient or his/her guardian * Known heart, kidney, liver failure * The initial cause of shock is neurogenic, cardiogenic or obstructive shock. * Pregnancy or suspected pregnancy * Those with amputation or severe organ ischemia * Those with peripheral artery disease * Cannot be evaluated optimally with transthoracic echo * Patients who died in the first 24 hours
Where this trial is running
Samsun, Ilkadim
- Samsun University — Samsun, Ilkadim, Turkey (Recruiting)
Study contacts
- Principal investigator: Ozgur Komurcu, 1 — Samsun University
- Study coordinator: Ozgur Komurcu, 1
- Email: zgrkom@gmail.com
- Phone: 90 5055273180
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.