Evaluating eye movement in patients with Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the progression of eye movement markers in patients with mild to moderate Parkinson's disease over a seven-year period. It aims to correlate neurological and neuropsychological evaluations with eye movement assessments using video-oculography. Additionally, the study will assess the impact of antiparkinsonian medications on eye movement evolution and determine the potential of eye movement assessments as a marker for disease progression.

Why it matters

Who can join: the full rules

\*Inclusion Criteria:

1. Male or Female;
2. Clinically defined idiopathic Parkinson's Disease (PD);
3. Brain MRI performed in routine care in the 12 months preceding inclusion;
4. Cerebral DaTSCAN or cerebral PET with F-DOPA, performed as routine care before inclusion (no time limit), confirming presynaptic dopaminergic denervation;
5. Hoehn \& Yahr score: 1 to 3;
6. Normal clinical examination of oculomotricity (slight impairment of smooth pursuit accepted);
7. Neuro-cognitive disorders: absent or minor (according to DSM5);
8. Sufficient written and oral expression in French;
9. Covered by a health insurance system;
10. Written informed consent signed by the patient;
11. Presence of a caregiver.

    \* Exclusion Criteria:
12. Psychiatric comorbidity (except anxiety or mild to moderate depression);
13. Neurological comorbidity, if significant;
14. Brain MRI showing:

    1. significant cerebrovascular pathology (Fazekas I admitted),
    2. another brain disease, including stroke.
15. Major cognitive impairment;
16. Absolute exclusion criteria and "Red flags" of the 2015 criteria orienting towards another degenerative pathology of the extrapyramidal system:

    * Cerebellar syndrome
    * Vertical oculomotricity disorders on clinical examination
    * Motor symptoms restricted to the lower limbs
    * Bilateral and perfectly symmetrical parkinsonism
    * Early dystonia
    * Clinical profile suggestive of behavioral variant frontotemporal dementia (bvFTD)
    * Progressive aphasia or apraxia
    * Moderate or severe postural instability and / or early falls
    * Early bulbar dysfunction (dysarthria, swallowing disorders)
    * Ventilatory dysfunction (inspiration)
    * Severe dysautonomia
    * DOPA-resistance
    * Neuroleptic treatment or related
17. Normal MIBG myocardial scintigraphy (if performed).

Where it's running

• Centre Mémoire / Centre de Gérontologie Clinique Rainier III / Princess Grace Hospital
  Monaco, Monaco Recruiting

Study contacts

• Principal investigator: Sandrine LOUCHART DE LA CHAPELLE, MD-PHD — Centre Mémoire, Centre de Gérontologie Clinique RAINIER III, Princess Grace Hospital, Monaco
• Study coordinator: Solange HESSE
• Email: solange.hesse@chpg.mc
• Phone: +377 99995599

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• MediPD: A Online Mediterranean Diet Plan for People Living with Parkinson's

  This pilot test checks if an online MediPD Mediterranean-diet program is practical and appealing for people with Parkinson's and whether it helps them start and keep a Mediterranean-style eating pattern.

  Recruiting Queen's University, Belfast · Belfast · NCT07838675

• Detecting freezing of gait at home using AI and wearable sensors

  This project tests whether an AI algorithm using wearable sensors can accurately detect freezing of gait in people with Parkinson's disease while they go about daily life at home.

  Recruiting KU Leuven · Leuven and 2 other locations · NCT07580612

• How deep brain stimulation affects speech and swallowing in Parkinson disease

  This study will test whether deep brain stimulation to the subthalamic nucleus (STN) or globus pallidus interna (GPi) changes voice, speech, swallowing, and cough in people with idiopathic Parkinson disease who are approved for first-time DBS surgery.

  Recruiting University of Florida · Gainesville, Florida · NCT07026734

• Strength and endurance training for people with Parkinson's disease

  This study is testing if combining strength training with aerobic exercise can help people with Parkinson's disease improve their physical performance and quality of life better than just aerobic exercise alone.

  Recruiting General University Hospital, Prague · Prague, Prague · NCT06893055

• Adaptive Deep Brain Stimulation for Parkinson's Disease Management

  This study tests whether adaptive deep brain stimulation (aDBS) using the AlphaDBS system can improve symptoms and reduce dyskinesias in adults with Parkinson’s disease compared to conventional DBS.

  Recruiting Newronika · Monza · NCT06891781

• Community walking program for people with Parkinson's disease

  This study tests a 6-month walking program for people with Parkinson's disease and their caregivers to see if it helps them stay active and connected with others.

  Recruiting St. Louis University · St Louis, Missouri · NCT06859528

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.