Evaluating electrolyte balance in hyponatremia treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the evolution of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia. It will gather prospective data to correlate initial sodium levels with plasma sodium evolution and electrolyte-free water changes. The study will also analyze anthropometric data and physiological responses to treatment, focusing on mechanisms of osmotic homeostasis and cell volume control. By understanding these patterns, the study seeks to improve treatment strategies for hyponatremia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients ≥ 18 years
* Hypotonic hyponatremia

  * glucose-corrected plasma sodium \<130 mmol/l
  * serum osmolality \<280 mosmol/kg or lack of signs of non-hypotonic hyponatremia

Exclusion Criteria:

* Signs of extracellular volume expansion
* Patients with liver cirrhosis and severe liver damage AST/ALT\>3xULN, AP\>6xULN, Bilirubin ≥ 3mg/dl
* Patients with heart failure
* Patients on dialysis and/or patients with oliguric renal impairment and plasma creatinine ≥ 3mg/dl
* Patients after organ transplantation

Where it's running

• University Hospital of Cologne
  Cologne, Germany Recruiting

Study contacts

• Principal investigator: Volker Burst, MD, Prof. — University Hospital of Cologne
• Study coordinator: Volker Burst, MD, Prof
• Email: volker.burst@uk-koeln.de
• Phone: +49 221-478-97222

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.