Evaluating EGFR-TKI treatments in lung cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with advanced non-small cell lung cancer (NSCLC) and aims to analyze the effectiveness of EGFR-TKI treatments such as gefitinib, erlotinib, and osimertinib. It seeks to establish a sensitive method for detecting mutations in plasma and to explore the relationship between somatic and germline mutations, drug concentration, and treatment outcomes. The study will also investigate how pharmacokinetic and pharmacodynamic factors influence drug efficacy and adverse reactions. In vivo and in vitro research will complement the clinical findings to provide a comprehensive understanding of these phenomena.

Why it matters

Who can join: the full rules

Inclusion Criteria:

The main patient entry criteria included: age≥ 18 years ; histologically and cytologically proved NSCLC; Eastern cooperative oncology group performance status (ECOG PS)≤2; adequate hematological , renal, and hepatic functions. Exclusion Criteria:

uncontrolled systemic disease ,any evidence of clinically active interstitial lung diseases, and other chemotherapy at the time of inclusion. The protocol was approved by the Ethical Committee of Cancer Center of Sun Yat-Sen University (CCSU), and written informed consent was obtained form each patient.

Where it's running

• Cancer Center, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: shaoxing guan, PHD
• Email: guanshx6@mail.sysu.edu.cn
• Phone: +86 13129351756

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.