Evaluating effects of different electrical stimulation patterns in epilepsy patients
Evaluating Modulation Effects of Burst Stimulation Patterns Using SEEG
This study is testing different patterns of electrical stimulation in epilepsy patients with implanted electrodes to see how they affect seizure activity and brain function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 14 Years to 65 Years |
| Sex | All |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06667232 on ClinicalTrials.gov |
What this trial studies
This study investigates the modulation effects of various electrical stimulation patterns in patients with drug-resistant epilepsy who have SEEG electrodes implanted. It compares single-pulse, paired-pulse, stepwise frequency, and burst stimulation to assess their impact on focal and network modulation during resting and post-seizure states. The research aims to enhance understanding of how different stimulation paradigms can influence seizure activity and brain function.
Who should consider this trial
Good fit: Ideal candidates are individuals with drug-resistant focal epilepsy who require SEEG exploration for presurgical assessment.
Not a fit: Patients who are pregnant, have psychiatric disorders, or a history of serious cranial trauma may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients with drug-resistant epilepsy.
How similar studies have performed: Other studies have shown promise in using electrical stimulation for epilepsy treatment, but this specific approach is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Drug-resistant focal epilepsy * Justified SEEG exploration in the context of presurgical assessment of epilepsy * Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis * Written non-opposition to study participation Exclusion Criteria: * Pregnant women (Contraindication to SEEG exploration) * Psychiatric disorders * History of psychotic disorders * History of cranial trauma serious (according to the classification), previous or evolutionary other neurological pathology * Subjects that experience surgical complications during the implant procedure will be excluded from the study
Where this trial is running
Beijing, Beijing Municipality
- Xuanwu Hospital,Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Liankun Ren, MD — Xuanwu Hospital, Beijing
- Study coordinator: Liankun Ren, MD
- Email: renlk2022@outlook.com
- Phone: +86 13681576621
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.