Evaluating ECMO and CRRT combination approaches for kidney failure
Separation Versus Integrated Approach in Combining ECMO With CRRT, a Randomized Controlled Trial
This study is testing if using a combination of heart and lung support with kidney treatment can help people with severe kidney injury and how it affects the treatment equipment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Chulalongkorn University Academic / other |
| Locations | 1 site (Bangkok) |
| Trial ID | NCT05036616 on ClinicalTrials.gov |
What this trial studies
This investigation aims to assess the effectiveness and complications of combining extracorporeal membrane oxygenation (ECMO) with continuous renal replacement therapy (CRRT) in patients with acute kidney injury (AKI). The study will focus on evaluating the filter lifetime of the CRRT membrane when used in conjunction with ECMO. By observing patients who meet specific criteria, the study seeks to gather data on the outcomes and potential benefits of this combined treatment approach.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old suffering from refractory acidosis, volume overload, hyperkalemia, or severe acute kidney injury.
Not a fit: Patients who are pregnant, have chronic kidney disease, or specific types of kidney injury such as glomerulonephritis or urinary tract obstruction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment strategies for patients with severe kidney failure and associated complications.
How similar studies have performed: While this approach is being evaluated, similar studies combining ECMO and CRRT have shown promise, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. \> 18 years 2. Refractory acidosis (pH\<7.2 or HCO3\<15) 3. Refractory volume overload 4. Refractory hyperkalemia (K\>6.2mEq/L or EKG change) 5. Anuria or oliguria (urine output \<0.5 mL/kg/hr for 6-12hr) 6. High BUN \>100 mg/dL or uremic symptom 7. Increase intracranial pressure Exclusion Criteria: 1. Pregnancy 2. Not use heparin in ECMO 3. Chronic kidney disease with CRRT 4. AKI with Glomerulonephritis, Interstitial nephritis, Vassculitis or Urinary tract obstruction
Where this trial is running
Bangkok
- Sasipha tachaboon — Bangkok, Thailand (Recruiting)
Study contacts
- Study coordinator: Sasipha tachaboon
- Email: sasipha_tac@hotmail.com
- Phone: 6622564000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.