Evaluating duodenal tissue samples during endoscopy
Optimization of Duodenal Tissue Resection Acquisition Study
NA · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · NCT06333093
This study is testing better ways to collect and prepare tissue samples from the duodenum during endoscopy to help understand how they relate to metabolic syndrome and type 2 diabetes in patients already scheduled for the procedure.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (other) |
| Locations | 1 site (Amsterdam, North-Holland) |
| Trial ID | NCT06333093 on ClinicalTrials.gov |
What this trial studies
This study aims to improve the quality of duodenal mucosa tissue samples obtained through cold snare resections during upper gastrointestinal endoscopy. By optimizing the processes of obtaining, storing, processing, and staining these samples, the researchers hope to better assess histological changes associated with metabolic syndrome and type 2 diabetes. The study focuses on patients already scheduled for endoscopy, allowing for a targeted approach to understanding the duodenum's role in metabolic health.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for upper gastrointestinal interventional endoscopy under deep sedation.
Not a fit: Patients with a history of duodenal inflammatory diseases or previous gastrointestinal surgeries affecting duodenal access may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic techniques and new treatment options for metabolic syndrome and type 2 diabetes.
How similar studies have performed: While the approach of optimizing tissue sample processing is not widely tested, similar studies have shown promise in improving histological assessments in other gastrointestinal contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Already scheduled to undergo an upper gastrointestinal interventional endoscopy * Endoscopy under deep sedation (propofol) in Amsterdam UMC Exclusion Criteria: * Previous GI surgery that could affect the ability to reach the duodenum via endoscopy, such as Bilroth 2, Roux-en-Y gastric bypass, or other similar procedures or condition * History of duodenal inflammatory diseases including Crohn's Disease and Celiac Disease
Where this trial is running
Amsterdam, North-Holland
- Amsterdam UMC — Amsterdam, North-Holland, Netherlands (RECRUITING)
Study contacts
- Principal investigator: Jacques JG Bergman, MD PhD — Amsterdam UMC
- Study coordinator: Celine BE Busch, MD
- Email: c.b.busch@amsterdamumc.nl
- Phone: 0031621357593
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Duodenum Disease