Evaluating drug reactions in patients taking multiple medications using genome sequencing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess adverse drug reactions (ADRs) in patients who are on five or more medications, utilizing advanced pharmacogenomic technology. The research will analyze genetic data to optimize medication regimens and develop a clinical decision support dashboard to identify necessary changes in drug therapies. Additionally, the study will evaluate the capacity of CYP P450 enzymatic pathways in these patients and assess the feasibility of integrating genomic data into clinical workflows. The ultimate goal is to enhance patient safety and medication management in polypharmacy scenarios.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals taking 5 or more medications, including over the counter drugs, supplements, natural products, cannabis produces, or other recreational drugs.
* Ability to give and comprehend the consent process.
* Consent to donate urine samples, genetic data through buccal swabs and blood samples, and undergo a comprehensive history and physical examination.
* All genders
* Age 18-100

Exclusion Criteria:

* Subject has been diagnosed or is being treated for any cancer other than basal cell cancer in the last 5 years. Patients with metastatic melanoma in the last 5 years will be excluded.
* Admitted to hospice.
* Patient has ever been diagnosed with Hepatitis B or C.
* Patient has ever been diagnosed with active liver disease, hepatomegaly, grossly abnormal liver function. Meld score \>10, ALT, or AST \>100U/L or an AST/ALT ratio \>2
* Patients taking imidazole antifungal medication.
* Declines to participate or interact with staff/share their medical status.
* A diagnosis of Alzheimer's disease or related dementias in a medical record indicates a progressive, debilitating condition that impairs memory, thought processes, and functioning.
* Pregnant patients will be excluded.
* Individuals who are unable or unwilling to provide consent will be excluded.
* Unable to verbally communicate and comprehend English language.

Where it's running

• Texas A&M Family Care
  Bryan, Texas, United States Recruiting

Study contacts

• Study coordinator: Kenneth S Ramos,, MD
• Email: kramos@tamu.edu
• Phone: 7136777740

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Registry for understanding how genes affect medication responses

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• Using genetic testing to improve medication safety for children

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  Recruiting at 2 sites University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT04249375

• Identifying genetic factors in drug reactions in children and adults

  This study is trying to find out if genetic differences in children and adults can help explain why some people have bad reactions to medications while others do not.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT00414115

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.