Evaluating drug-coated balloons for new coronary artery lesions

Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion

Ulsan Medical Center · NCT04619277

This study is testing whether drug-coated balloons can safely and effectively treat new coronary artery blockages better than traditional methods like regular balloon angioplasty and drug-eluting stents.

Quick facts

Study typeObservational
Enrollment10000 (estimated)
SexAll
SponsorUlsan Medical Center (other)
Locations1 site (Ulsan)
Trial IDNCT04619277 on ClinicalTrials.gov

What this trial studies

This international multicenter registry focuses on the use of drug-coated balloons (DCBs) for treating de novo coronary lesions. The study aims to assess the safety and efficacy of DCBs compared to traditional methods like plain old balloon angioplasty and drug-eluting stents. By analyzing clinical and angiographic outcomes, the research seeks to provide insights into the long-term benefits of DCBs in this patient population. The study is particularly relevant given the limited data on DCB-only approaches for new coronary lesions.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals diagnosed with de novo coronary artery disease.

Not a fit: Patients with unstable hemodynamics at presentation or a life expectancy of less than one year may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment options for patients with de novo coronary artery disease, potentially reducing complications and enhancing long-term outcomes.

How similar studies have performed: While studies on DCBs for in-stent restenosis have shown success, the application of DCBs for de novo lesions is less explored, making this approach relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- de novo coronary artery disease

Exclusion Criteria:

* unstable hemodynamics at presentation
* life expectancy \<1 year

Where this trial is running

Ulsan

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Drug-coated Balloon

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.