Evaluating Doxycycline Nanoparticles with Gelatin Sponge for Immediate Dental Implants
Clinical and Radiographic Evaluation of Doxycycline and Doxycycline Loaded Nanoparticles With Gelatin Sponge on Immediate Implant Placement in Esthetic Zone: A Randomized Clinical Trial
This study tests if using doxycycline nanoparticles with a gelatin sponge can improve the success of immediate dental implants compared to standard treatment for patients getting implants in the front of their mouth.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 16 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Kafrelsheikh University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Kafrelsheikh, Kafrelsheikh) |
| Trial ID | NCT06809829 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to assess the effectiveness of doxycycline nanoparticles combined with a gelatin sponge in enhancing the outcomes of immediate dental implant placements in the esthetic zone. The study will involve two groups of patients: one receiving implants with doxycycline-loaded nanoparticles and gelatin sponge, and the other receiving implants with standard doxycycline and gelatin sponge. Researchers will compare clinical and radiographic results between these two groups to determine if the nanoparticle formulation provides superior benefits.
Who should consider this trial
Good fit: Ideal candidates include individuals with non-restorable single-rooted maxillary teeth who have sufficient bone volume and good oral hygiene.
Not a fit: Patients with insufficient bone volume, active infections, or systemic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved healing and aesthetic outcomes for patients receiving immediate dental implants.
How similar studies have performed: While the use of nanoparticles in dental applications is emerging, this specific combination of doxycycline nanoparticles and gelatin sponge for immediate implants is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* The presence of non-restorable single-rooted maxillary centrals, canines or premolars.
* Sufficient bone volume.
* Good oral hygiene.
* The remaining space between the socket and the fixture equals or more than 2mm at the coronal third of the socket.
* Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).
Exclusion Criteria:
* Insufficient bone volume.
* Active infection.
* Patients on chemotherapy or radiotherapy.
* Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, …etc},
* Pregnant patients,
* Patients with bone diseases
* Presence of periapical pathology affecting the neighbouring teeth.
* Smokers.
Where this trial is running
Kafrelsheikh, Kafrelsheikh
- Faculty of dentistry kafrelsheikh university — Kafrelsheikh, Kafrelsheikh, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.