Evaluating diaphragm performance during weaning from mechanical ventilation
Official title: Evaluation of the Diaphragm Tissue Doppler Parameters in Predicting Weaning From Mechanical Ventilation Outcome
Run by Mongi Slim Hospital · NCT06203353 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study looks at how well the diaphragm works in adult ICU patients who are trying to stop using a breathing machine to see if it can help predict their success in weaning off the ventilator.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Mongi Slim Hospital Academic / other |
| Locations | 1 site (Tunis) |
| Trial ID | NCT06203353 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult ICU patients requiring invasive mechanical ventilation for more than 48 hours with a Glasgow Coma Scale score greater than 13.
✕Probably not a fit
Patients who may not benefit include those with chronic respiratory failure or those requiring reintubation for reasons unrelated to respiratory issues.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study involves adult ICU patients who have been on invasive mechanical ventilation for at least 48 hours. It focuses on assessing diaphragm function through ultrasound before conducting a T tube spontaneous breathing test during the weaning process. Key parameters such as diaphragm excursion, thickening fraction, and contraction velocities will be measured to predict weaning outcomes. Patients will be categorized based on their success in weaning from mechanical ventilation, allowing for a comparison of diaphragm ultrasound patterns between groups.
Why it matters
Potential benefit: If successful, this study could improve the understanding of diaphragm function and enhance weaning protocols from mechanical ventilation.
How similar studies have gone: While diaphragm ultrasound has been explored in other contexts, this specific approach to predicting weaning outcomes is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Invasive mechanical ventilation for at least 48 hours Exclusion Criteria: * reintubation for extra respiratory failure (neurologic or hemodynamic) * Patients with chronic repiratory failure
Where it's running
-
Mongi Slim hospital
Tunis, Tunisia Recruiting
Study contacts
- Study coordinator: Mhamed Mebazaa, professor
- Email: msmebazaa@gmail.com
- Phone: 22252589
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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High Flow Tracheal Oxygen to Help Wean Tracheostomy Patients from Ventilation
This trial tests whether delivering high-flow oxygen directly through the trachea helps tracheostomized patients on mechanical ventilation try to come off ventilation faster than standard tracheal mask therapy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.