Evaluating diaphragm performance during weaning from mechanical ventilation
Evaluation of the Diaphragm Tissue Doppler Parameters in Predicting Weaning From Mechanical Ventilation Outcome
This study looks at how well the diaphragm works in adult ICU patients who are trying to stop using a breathing machine to see if it can help predict their success in weaning off the ventilator.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mongi Slim Hospital Academic / other |
| Locations | 1 site (Tunis) |
| Trial ID | NCT06203353 on ClinicalTrials.gov |
What this trial studies
This observational study involves adult ICU patients who have been on invasive mechanical ventilation for at least 48 hours. It focuses on assessing diaphragm function through ultrasound before conducting a T tube spontaneous breathing test during the weaning process. Key parameters such as diaphragm excursion, thickening fraction, and contraction velocities will be measured to predict weaning outcomes. Patients will be categorized based on their success in weaning from mechanical ventilation, allowing for a comparison of diaphragm ultrasound patterns between groups.
Who should consider this trial
Good fit: Ideal candidates are adult ICU patients requiring invasive mechanical ventilation for more than 48 hours with a Glasgow Coma Scale score greater than 13.
Not a fit: Patients who may not benefit include those with chronic respiratory failure or those requiring reintubation for reasons unrelated to respiratory issues.
Why it matters
Potential benefit: If successful, this study could improve the understanding of diaphragm function and enhance weaning protocols from mechanical ventilation.
How similar studies have performed: While diaphragm ultrasound has been explored in other contexts, this specific approach to predicting weaning outcomes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Invasive mechanical ventilation for at least 48 hours Exclusion Criteria: * reintubation for extra respiratory failure (neurologic or hemodynamic) * Patients with chronic repiratory failure
Where this trial is running
Tunis
- Mongi Slim hospital — Tunis, Tunisia (Recruiting)
Study contacts
- Study coordinator: Mhamed Mebazaa, professor
- Email: msmebazaa@gmail.com
- Phone: 22252589
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.