Evaluating dexmedetomidine for neuroprotection in brain injury patients
Effect of Dexmedetomidine on Brain Injury Patients
This study is testing if a medication called dexmedetomidine can help protect the brains of patients with brain injuries while they are in the intensive care unit.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Damanhour University Academic / other |
| Locations | 1 site (Damanhūr, Elbehairah) |
| Trial ID | NCT06661980 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to investigate the neuroprotective effects of dexmedetomidine in patients suffering from brain injuries. A total of 60 patients will be enrolled and randomly assigned to receive either dexmedetomidine or a placebo. The study will monitor changes in patients' symptoms and biomarker levels during their stay in the intensive care unit. Statistical analyses will be conducted to assess the significance of the outcomes, providing insights into the potential benefits of dexmedetomidine for brain injury patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 70 with diagnosed brain injuries.
Not a fit: Patients with significant liver impairment, heart failure, hypotension, or bradycardia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients with brain injuries by demonstrating the neuroprotective properties of dexmedetomidine.
How similar studies have performed: While the specific neuroprotective effects of dexmedetomidine in brain injury patients are not widely studied, similar approaches have shown promise in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 60 Patients with brain injury with age ranging from 18 to 70 years, there are no limits to gender. Exclusion Criteria: * Patients with significant liver impairment * Patients with known heart failure * Patients with hypotension * Patients with bradycardia
Where this trial is running
Damanhūr, Elbehairah
- Damanhour Teaching Hospital, General Organization for Teaching Hospitals and Institutes. — Damanhūr, Elbehairah, Egypt (Recruiting)
Study contacts
- Study coordinator: Rehab H Werida, Ass. Prof.
- Email: rehabwrieda@pharm.dmu.edu.eg
- Phone: 01005359968
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.