Evaluating Cytisine for Smoking Cessation

Analysis and Evaluation of Smoking Treatment With Cytisine: Retrospective Observational Study

Observational Regina Elena Cancer Institute · NCT06439303

This study tests if Cytisine can help people with moderate to severe tobacco addiction quit smoking successfully.

Quick facts

Study typeObservational
Enrollment65 (estimated)
Ages18 Years and up
SexAll
SponsorRegina Elena Cancer Institute Academic / other
Locations1 site (Rome)
Trial IDNCT06439303 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the effectiveness of Cytisine, a medication prescribed for smoking cessation, in patients with moderate to severe tobacco use disorder. It involves a retrospective analysis of patients who underwent an initial examination at the Anti-Smoking Center of the National Institute Regina Elena. The study will evaluate treatment adherence, efficacy, and tolerability of Cytisine as a monotherapy for smoking cessation during a specified period. Data will be collected from patients who attended follow-up visits after receiving the treatment.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old suffering from moderate or severe tobacco use disorder who are prescribed Cytisine.

Not a fit: Patients with contraindications to Cytisine or those undergoing treatment for neoplastic conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a cost-effective therapeutic alternative for individuals struggling with tobacco addiction.

How similar studies have performed: While there is limited research on Cytisine specifically, other studies on smoking cessation treatments have shown varying degrees of success, indicating potential for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients aged \> 18 years;
* patients suffering from moderate or severe tobacco use disorder;
* prescription of pharmacological therapy with Cytisine;
* patients returned to the 1st check-up on schedule;

Exclusion Criteria:

* Patients with contraindications to taking Cytisine and partial receptor agonists nicotinic cholinergics;
* Patients undergoing pharmacological or physical treatment for neoplastic pathology;
* Pregnant or breastfeeding women;
* Patients for whom specific information for objective assessments is not available;

Where this trial is running

Rome

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Moderate or Severe Tobacco Use Disorder
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.