Evaluating counterpressure maneuvers for treating Postural Orthostatic Tachycardia Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of a 14-day counterpressure maneuvers (CPM) biofeedback training in alleviating symptoms of Postural Orthostatic Tachycardia Syndrome (POTS). Participants will be randomly assigned to receive either the CPM training alongside best clinical practice or best clinical practice alone. The study aims to assess improvements in symptom burden, daily activity interference, fatigue, and quality of life, as well as the hemodynamic effects of CPM on heart rate and blood pressure. Safety and tolerability of the intervention will also be evaluated.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* POTS diagnosis
* 18 to 80 years of age at time of consent
* stable medication in the seven days prior to the baseline visit
* able to provide written informed consent

Exclusion Criteria:

* participation in other interventional trials
* pregnant or breastfeeding females
* on treatment with vasoactive medications including medications for heart rate control
* acute infections at the time of enrolment or in the two weeks before
* acute pain
* surgery in the last three months
* inability or contraindication for performing hip and knee flexion, hip adduction or squatting
* inability to stand for at least two minutes
* Any other cardiological, internal, psychiatric or neurological condition, which may prevent engagement in the sturdy procedures in the judgement of the investigator

Where it's running

• Medical University of Innsbruck
  Innsbruck, Tyrol, Austria Recruiting

Study contacts

• Study coordinator: Alessandra Fanciulli, MD, PhD
• Email: alessandra.fanciulli@i-med.ac.at
• Phone: +43 512 504 83238

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.