Evaluating coronary artery disease risk using advanced imaging and AI
Coronary Computed Tomography Angiography and Functional Analysis in Risk Stratification of Coronary Artery Disease: A Retrospective Cohort Study
This study is testing whether advanced imaging and artificial intelligence can help doctors better understand the risk of coronary artery disease in patients who have had a heart attack.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Ruijin Hospital Academic / other |
| Locations | 9 sites (Cangzhou, Hebei and 8 other locations) |
| Trial ID | NCT05884008 on ClinicalTrials.gov |
What this trial studies
This multicenter, retrospective imaging study aims to enroll patients who experienced acute myocardial infarction and had undergone coronary CTA within a specific timeframe prior to the event. The study will utilize anatomic, functional, and radiomic analyses, enhanced by artificial intelligence, to develop a risk stratification system for coronary artery disease. By addressing the limitations of traditional coronary angiography, this research seeks to improve the accuracy of risk assessments and treatment decisions for patients with coronary artery disease.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-80 who have had coronary CT angiography within 3 months to 5 years prior to an acute myocardial infarction.
Not a fit: Patients with familial hypercholesterolemia, prior history of PCI or CABG, previous myocardial infarction, or severe liver or renal insufficiency may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate risk stratification and improved treatment outcomes for patients with coronary artery disease.
How similar studies have performed: Other studies utilizing advanced imaging techniques and AI for coronary artery disease risk assessment have shown promising results, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18-80 years old * Received coronary CT angiography 3 months to 5 years prior to acute coronary myocardial infarction. CCTA identified coronary atherosclerotic plaques with diameter stenosis ≥ 10% Exclusion Criteria: * Familial hypercholesterolemia * Prior history of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) * Prior history of myocardial infarction before the recent event * Severe liver or renal insufficiency
Where this trial is running
Cangzhou, Hebei and 8 other locations
- Cangzhou Center Hospital — Cangzhou, Hebei, China (Recruiting)
- First affiliated hospital of Harbin Medical University — Harbin, Heilongjiang, China (Recruiting)
- First affiliated hospital of Zhengzhou University — Zhengzhou, Henan, China (Recruiting)
- Union Hospital, Tongji Medical College, Huazhong University of Science and Techonology — Wuhan, Hubei, China (Recruiting)
- First Hospital of Nanjing — Nanjing, Jiangsu, China (Recruiting)
- First affiliated hospital of Dalian Medical College — Dalian, Liaoning, China (Recruiting)
- General Hospital of Northern Theater Command — Shenyang, Liaoning, China (Recruiting)
- Ruijin Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, Shanghai Municipality, China (Recruiting)
- Xinhua Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Principal investigator: Ruiyan Zhang, M.D., Ph.D. — Ruijin Hospital
- Study coordinator: Xiaoqun Wang, M.D., Ph.D.
- Email: xiaoqun_wang@hotmail.com
- Phone: +86 13651839760
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.