Evaluating cognitive training effects in Parkinson's patients with GBA mutations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess how the GBA gene mutation influences the response to cognitive stimulation treatment in patients with Parkinson's disease. Participants will undergo neuropsychological evaluations and genetic testing before being included in cognitive stimulation programs. The study will compare the effectiveness of cognitive training between patients with the GBA mutation and those without it, while also examining the impact on behavioral aspects resulting from cognitive improvements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with Parkinson's disease according to the Gelb et al. criteria;
* Patients who have carried out genetic screening for MP;
* Patients who have a raw score in the range 15.50 to 22.23 at Montreal cognitive assessment (MoCA);
* Patients who have signed the informed consent and the Privacy Policy;
* Patients who are included in cognitive stimulation programs according to regular clinical practice.

Exclusion Criteria:

* Patients with the initial suspicion of MP that during the diagnostic work-up they were suffering from a different pathology;
* Patients who have refused consent to participate in the study;
* Patients with a diagnosis of MP and cognitive profile of dementia;
* Patients undergoing deep brain neurostimulation (DBS-STN) treatment. Patients treated with DBS-STN were excluded because such treatment involves a surgical procedure whose effects on cognitive functioning could represent an interfering variable.

Where it's running

• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
  Milan, Italy Recruiting

Study contacts

• Study coordinator: Fabiana Ruggiero, MSc in Psychology
• Email: fabiana.ruggiero@policlinico.mi.it
• Phone: +390255033621

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.