Evaluating cognitive risks after epilepsy surgery using imaging techniques
Evaluation of the Risk of Cognitive Deficit After Surgery of Epilepsy by Dynamic Spectral Imaging (ISD) of the Cognitive Functions in Patients Explored in StereoElectroEncephaloGraphy (SEEG)
This study is testing if special brain imaging can help find the best spot for epilepsy surgery while making sure it won’t hurt people’s thinking skills afterwards.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT03094312 on ClinicalTrials.gov |
What this trial studies
This study evaluates the cognitive risks associated with epilepsy surgery by using Dynamic Spectral Imaging (ISD) in patients undergoing StereoElectroEncephaloGraphy (SEEG). It aims to identify the location and extent of the epileptogenic zone (EZ) while assessing potential functional risks before surgical intervention. The study includes a thorough assessment of patients with drug-resistant focal epilepsy to ensure that surgery does not lead to significant cognitive impairment. Participants will undergo imaging examinations, neuropsychological assessments, and long-term video-EEG recordings as part of their pre-surgical evaluation.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-65 with drug-resistant focal epilepsy who are scheduled for SEEG exploration.
Not a fit: Patients under 18 or over 65, those not suffering from drug-resistant focal epilepsy, or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help minimize cognitive deficits in patients undergoing epilepsy surgery.
How similar studies have performed: Other studies have shown success in using imaging techniques to assess cognitive risks in epilepsy surgery, indicating that this approach is promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient adult (18-65 y/o) without legal protection measures * Patient with a drug-resistant focal epilepsy * Patient with a SEEG exploration as part of pre-surgical assessment of epilepsy * patient with a consent form signed * Intellectual capacities compatible with cognitive tasks and the signing of informed consent * Affiliation to the social security Exclusion Criteria: * Pregnant women: this is already a contraindication to the realization of a SEEG study * Subjects under 18 years of age or over 65 years of age * Patient not suffering from EFPR, or not scheduled for SEEG * Intellectual capacities incompatible with the cognitive tasks and / or the signature of a consent
Where this trial is running
Bron
- Hospices Civils de Lyon — Bron, France (Recruiting)
Study contacts
- Principal investigator: Sylvain RHEIMS, MD — Hospices Civils de Lyon
- Study coordinator: Sylvain RHEIMS, MD
- Email: sylvain.rheims@chu-lyon.fr
- Phone: 472359343
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.