Evaluating CO2 Lift for Reducing Bruising and Pain After Liposuction

Bridging the Healing Gap: A Single-Blind Clinical Trial Assessing the Efficacy of Carboxy-gel in Reducing Bruising and Pain Post-Liposuction

Phase 4 Interventional Total Definer Research Group · NCT06791577

This study is testing if a CO2 treatment can help reduce bruising and pain after liposuction compared to a placebo.

Quick facts

PhasePhase 4
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorTotal Definer Research Group Academic / other
Locations3 sites (São Paulo and 2 other locations)
Trial IDNCT06791577 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to assess the efficacy of CO2 Lift in reducing bruising and pain following liposuction procedures. It employs a randomized, controlled, single-blind design where participants receive CO2 Lift on one area of their body and a placebo (Vaseline) on a contralateral area. The study will measure outcomes such as the extent of bruising at 7 days post-surgery, pain levels using a Visual Analogue Scale, and patient satisfaction through the Global Aesthetic Improvement Scale. Data will be collected through photographic analysis and patient-reported outcomes over a period of time.

Who should consider this trial

Good fit: Ideal candidates are healthy individuals undergoing liposuction or liposculpture procedures without significant comorbidities.

Not a fit: Patients with a BMI of 32 kg/m2 or higher, pregnant individuals, or those with known allergies to CO2 Lift or Vaseline may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly enhance recovery experiences for patients undergoing liposuction by reducing postoperative bruising and pain.

How similar studies have performed: While the specific application of CO2 Lift in this context is novel, similar studies exploring the use of carboxytherapy for postoperative recovery have shown promising results.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients undergoing body contouring procedures (liposuction or liposculpture), either individually or combined with a maximum of two other major aesthetic procedures involving face, breast, or dermo-lipectomy.
* healthy patients without underlying comorbidities (classified as ASA≤II)

Exclusion Criteria:

* Pregnant patients
* Known allergy to CO2 Lift or Vaseline
* History of keloid formation or significant dermatological conditions.
* Coagulopathy or current use of anticoagulant therapy.
* Skin disorders related to collagen disease.
* BMI ≥ 32 kg/m2.

Where this trial is running

São Paulo and 2 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions LiposuctionBruisingInflammationPain, PostoperativeEcchymosisHematomaCarboxytherapyCO2 Lift
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.