Evaluating CM336 for patients with relapsed or refractory multiple myeloma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-center, open-label Phase 1/2 study in China aims to assess the safety, tolerability, efficacy, pharmacokinetics, pharmacodynamics, and immunogenicity of CM336 in patients suffering from relapsed or refractory multiple myeloma. The study is divided into two parts: Phase 1 focuses on dose escalation to determine the maximum tolerated dose, while Phase 2 evaluates the efficacy of the recommended dose. Patients will be monitored for their response to the treatment and any adverse effects throughout the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eastern Cooperative Oncology Group Performance Status (ECOG) of 0-2.
* Patients with relapsed or refractory MM who have failed or are intolerant to all therapies with known clinical benefit; patients must have received at least 2 prior anti-myeloma therapies which must contain at least one proteasome inhibitor (PI), one immunomodulatory drug (IMiD), and one anti-CD38 monoclonal antibody (if available).

Exclusion Criteria:

* Patients who had received BCMA-targeted therapy.
* Patients who had received CAR-T therapy.
* Patients who had received anti-tumor therapy within 3 weeks or 5 half-lives (whichever is shorter) prior to the first dose of CM336.

Where it's running

• Peking University Third Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Hongmei Jing — Peking University Third Hospital
• Study coordinator: Qian Jia
• Email: qianjia@keymedbio.com
• Phone: 028-88610620

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.