Evaluating Clopidogrel Resistance in Patients Undergoing Carotid Stenting
MULTIcentric Study About RESistance to CLOpidogrel in Dual Antiplatelet Therapy for Carotid Stenting
This study is testing whether switching to a different medication called Ticagrelor can help patients who don't respond well to Clopidogrel during carotid stenting procedures.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1140 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS Policlinico S. Donato Academic / other |
| Locations | 1 site (San Donato Milanese, Milan) |
| Trial ID | NCT05566301 on ClinicalTrials.gov |
What this trial studies
This observational multicentric study aims to assess the differences in outcomes between patients who respond to Clopidogrel and those who do not, specifically focusing on the use of Ticagrelor in non-responders undergoing carotid stenting. The study will collect clinical data, including patient demographics, cardiovascular risk factors, and laboratory results, to identify factors associated with Clopidogrel resistance. Patients will be followed up at multiple intervals post-procedure to monitor for major adverse cardiovascular events and bleeding complications. The goal is to improve understanding of antiplatelet therapy effectiveness in this patient population.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are undergoing carotid stenting and have consented to participate in the study.
Not a fit: Patients who are underage, pregnant, or have carotid stenosis not suitable for stenting will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with carotid stenosis, potentially reducing adverse cardiovascular events.
How similar studies have performed: While studies on antiplatelet therapy exist, this specific approach to evaluating Clopidogrel resistance in carotid stenting is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients (age\> 18 years) * patients who have given their consent to participate in the study, belonging to the U.O. of Vascular Surgery of the IRCCS Policlinico San Donato and the U.O. of Vascular Surgery of the participating centers and subjected to the treatment of carotid stenosis by stenting technique. Exclusion Criteria: * underage patients * patients who have not given their consent to participate in the study, * patients who have carotid stenosis not susceptible to intervention by stenting * pregnant or lactating women (such as situations in which carotid stenting is contraindicated regardless of the execution of the study).
Where this trial is running
San Donato Milanese, Milan
- IRCCS Policlinico San Donato — San Donato Milanese, Milan, Italy (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.