Evaluating Clareon Vivity Intraocular Lens with Mini-Monovision for Cataract Surgery

Clinical Outcomes of Clareon Vivity Intraocular Lens With Mini-Monovision Approach

Not applicable Interventional Palo Alto Medical Foundation · NCT05821101

This study is testing how well the Clareon Vivity lenses work for people having cataract surgery using a mini-monovision approach to see if it helps improve their vision without glasses.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment30 (estimated)
Ages18 Years and up
SexAll
SponsorPalo Alto Medical Foundation Academic / other
Locations1 site (Palo Alto, California)
Trial IDNCT05821101 on ClinicalTrials.gov

What this trial studies

This study investigates the clinical outcomes of the Clareon Vivity and Clareon Vivity Toric intraocular lenses (IOLs) in patients undergoing cataract surgery using a mini-monovision approach. In this approach, the dominant eye is corrected for distance vision while the non-dominant eye is slightly nearsighted, enhancing the range of vision without glasses. The study aims to gather additional data on the effectiveness of these lenses, which have already been approved by the FDA for visual correction in aphakia. The procedures involved are not experimental, but the study seeks to provide further insights into their clinical outcomes.

Who should consider this trial

Good fit: Ideal candidates are adults with bilateral age-related cataracts who are otherwise healthy and undergoing cataract surgery.

Not a fit: Patients with a history of ocular or refractive surgery or those with significant ocular or systemic comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve visual outcomes for cataract surgery patients by providing a broader range of clear vision without the need for glasses.

How similar studies have performed: Other studies have shown positive outcomes with similar lens technologies and approaches, indicating a promising avenue for further exploration.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult patients with bilateral age-related visually significant cataracts in otherwise healthy eyes, undergoing bilateral sequential implantation within 21 days using Clareon Vivity and Clareon Vivity Torics
* IOL powers between +10D to +30.0D, T3-T6
* Potential acuity measured post-operatively 20/25 or better in both eyes

Exclusion Criteria:

* History of ocular or refractive surgery
* Ocular or systemic comorbidities that may alter or reduce visual acuity, contrast sensitivity, binocularity, or impair reading performance such as severe dry eye/ocular surface disease, glaucoma, macular degeneration, retinopathy, neuro-ophthalmic diseases, strabismus/amblyopia etc.
* Patients with irregular astigmatism, corneal dystrophies, pupil abnormalities, zonular laxity
* Intraoperative or postoperative complications

Where this trial is running

Palo Alto, California

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Aphakia, Postcataract
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.