Evaluating cerebral compliance in neurosurgical intensive care units
Study of Cerebral Compliance in Neurosurgical Intensive Care Units (EC2)
This study is trying to see if measuring changes in pressure in the brain can help doctors understand how well the brain is working in patients with head injuries who are on mechanical ventilation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 7 sites (Chaponnay and 6 other locations) |
| Trial ID | NCT06350656 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on analyzing the shape of intracranial pressure wave components (P1, P2, and P3) in sedated patients on mechanical ventilation. By flattening patients during nursing care, the study aims to determine an index that defines cerebral compliance, which is currently lacking in clinical practice. The research involves collecting clinical and therapeutic data, as well as monitoring intracranial pressure values to better understand cerebrospinal compliance in the context of head injuries.
Who should consider this trial
Good fit: Ideal candidates include sedated patients on mechanical ventilation with continuous intracranial pressure monitoring.
Not a fit: Patients who have undergone craniectomy or are experiencing major hemodynamic failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of intracranial pressure in patients with head injuries.
How similar studies have performed: While the approach of evaluating cerebral compliance is novel, the study builds on existing practices of intracranial pressure monitoring, which have shown varying degrees of success in related research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Continuous intracranial pressure monitoring * Sedated patient on mechanical ventilation Exclusion Criteria: * Craniectomy * Major hemodynamic failure
Where this trial is running
Chaponnay and 6 other locations
- CENTRE HOSPITALIER Charponnay — Chaponnay, France (Recruiting)
- CENTRE HOSPITALIER UNIVERSITAIRE Grenoble — Grenoble, France (Recruiting)
- HOPITAL NORD La Tronche — La Tronche, France (Recruiting)
- Aphp — Paris, France (Recruiting)
- Hopital Lariboisiere - Ahph — Paris, France (Recruiting)
- CENTRE HOSPITALIER UNIVERSITAIRE Rennes — Rennes, France (Recruiting)
- CENTRE HOSPITALIER UNIVERSITAIRE Saint-Etienne — Saint-Étienne, France (Recruiting)
Study contacts
- Principal investigator: Laurent Gergele, Md — Chu de Saint-Etienne
- Study coordinator: Laurent Gergele, Md
- Email: laurent.gergele@chu-st-etienne.fr
- Phone: (0)477828593
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.