Evaluating brain stimulation effects on movement in stroke patients
Phase-dependent Evaluation of Motor Cortex Excitability With TMS in Stroke
This study tests if a brain stimulation technique can improve movement in stroke patients by looking at how it affects their brain's motor control.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT04968743 on ClinicalTrials.gov |
What this trial studies
This study investigates how transcranial magnetic stimulation (TMS) affects motor cortex excitability in individuals who have experienced a stroke. It aims to understand the influence of the phase of the oscillatory rhythm, specifically the mu frequency, on motor excitability. By measuring motor evoked potentials (MEPs) at different phases of the motor mu-rhythm, the study seeks to characterize differences in cortical excitability among stroke patients. The ultimate goal is to enhance rehabilitation strategies for improving movement in stroke survivors.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who have suffered a chronic stroke with self-reported motor deficits occurring more than six months prior to enrollment.
Not a fit: Patients with metal or electric implants in the head, neck, or chest area, or those who have had recent botulinum toxin treatment, pregnancy, or a history of unprovoked seizures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation techniques for stroke patients, enhancing their motor recovery.
How similar studies have performed: Previous studies have shown promising results with TMS in stroke rehabilitation, although this specific phase-dependent approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Suffering from chronic stroke, resulting in self-reported motor deficits (stroke occurring more than 6 months before study enrollment) * Confident level of English language Exclusion Criteria: * Metal or electric implant in the head, neck, or chest area * Upper extremity botulinum toxin treatment in the last 6 months * Pregnancy or breastfeeding * Prior occurrence of unprovoked seizure
Where this trial is running
Minneapolis, Minnesota
- University of Minnesota — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Alexander Opitz, PhD — University of Minnesota Department of Biomedical Engineering
- Study coordinator: Alexander Opitz, PhD
- Email: aopitz@umn.edu
- Phone: (612)-624-1094
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.