Evaluating brain stiffness in patients with high intracranial pressure
Evaluating Raised Intracranial Pressure Using MR Elastography
NA · Mayo Clinic · NCT03096743
This study is testing new ways to measure brain stiffness in people with high pressure inside the skull to see if it can help improve how we diagnose this condition.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic (other) |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT03096743 on ClinicalTrials.gov |
What this trial studies
This study aims to assess brain elasticity in patients with idiopathic intracranial hypertension and other conditions causing raised intracranial pressure. Researchers will compare MR elastography measurements with noninvasive methods like optical coherence tomography and MRI to detect elevated pressure. Additionally, the study will investigate the correlation between brain stiffness and lumbar puncture opening pressure, as well as changes in stiffness following various interventions. The goal is to improve diagnostic methods for raised intracranial pressure.
Who should consider this trial
Good fit: Ideal candidates include individuals with papilledema due to idiopathic intracranial hypertension or other forms of elevated intracranial pressure.
Not a fit: Patients under 18 years old, pregnant individuals, or those for whom MRI is contraindicated will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and noninvasive methods for diagnosing and monitoring raised intracranial pressure.
How similar studies have performed: Other studies have shown promise in using noninvasive imaging techniques for assessing intracranial pressure, but the specific approach of MR elastography is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
All subjects will have the following inclusion criteria: * Group 1: Papilledema from idiopathic intracranial hypertension and other forms of elevated intracranial pressure, including obstructive hydrocephalus * Group 2: Patients without raised intracranial pressure. All subjects will have the following exclusion criteria: * Age \<18 * Pregnancy (self-reported) * Individuals for whom MR is contraindicated
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (RECRUITING)
Study contacts
- Principal investigator: John J Chen, M.D., Ph.D. — Mayo Clinic
- Study coordinator: John J. Chen, M.D., Ph.D.
- Email: chen.john@mayo.edu
- Phone: 507-284-7140
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Idiopathic Intracranial Hypertension