Evaluating brain activity in laryngeal dystonia
Cortical Silent Period in Laryngeal Dystonia
This study is testing how brain activity affects voice control in people with laryngeal dystonia compared to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Sex | All |
| Sponsor | University of Split, School of Medicine Academic / other |
| Locations | 1 site (Split) |
| Trial ID | NCT05580302 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the cortical silent period (cSP) in the cricothyroid muscle of individuals with laryngeal dystonia compared to healthy controls. Using transcranial magnetic stimulation (TMS), the study will measure motor evoked potentials (MEPs) and the duration of cSP to establish normative data. The findings may provide insights into the cortical control mechanisms involved in phonation and how they are altered in laryngeal dystonia. By analyzing neurophysiological data, the study seeks to enhance understanding of this condition and its impact on speech.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-65 diagnosed with laryngeal dystonia.
Not a fit: Patients with other neurological disorders, psychiatric conditions, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for patients with laryngeal dystonia.
How similar studies have performed: While previous studies have explored TMS in laryngeal muscles, this specific investigation of cSP in the cricothyroid muscle is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adults (18-65 years old), no implanted metals in the body (e.g. pacemaker, metal prosthesis in the skull and oral cavity). Exclusion Criteria: * pregnancy, other neurological disorders (except laryngeal dystonia in the laryngeal dystonia group), psychiatric disorders, epilepsy or history of previous epilepsy attack, using of brain-affecting pharmaceuticals, traumatic, tumor, infectious, metabolic brain lesions, heart conditions. The composition of the group is represented is both gender, various age gap, and different height.
Where this trial is running
Split
- University of Split School of Medicine — Split, Croatia (Recruiting)
Study contacts
- Principal investigator: Maja Rogić Vidaković, PhD — University of Split, School of Medicine
- Study coordinator: Maja Rogić Vidaković, PhD
- Email: maja.rogic@mefst.hr
- Phone: +385098508210
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.