Evaluating bone loss around different types of dental implants
Evaluation of Marginal Bone Loss and Associated Factors Around Ziacom Dental Implants With Different Prosthetic Connection
This study is testing if different types of dental implants cause different amounts of bone loss and inflammation to see which one is better for keeping your bone health stable.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 42 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Universidad de Granada Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Granada) |
| Trial ID | NCT05859113 on ClinicalTrials.gov |
What this trial studies
This study investigates the marginal bone loss associated with Ziacom dental implants featuring different prosthetic connections. It aims to compare bone levels, bacterial contamination, and inflammatory markers around implants with conical connections versus those with internal hexagonal connections. The research will track these factors over time to understand their impact on bone health and implant stability. The hypothesis suggests that hexagonal connections may lead to greater bone loss due to a more harmful microbiome and increased inflammation.
Who should consider this trial
Good fit: Ideal candidates are individuals with one missing tooth in the premolar or molar area who have both opposing and adjacent teeth.
Not a fit: Patients with uncontrolled diabetes, autoimmune diseases, or severe hematologic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved dental implant designs that minimize bone loss and enhance patient outcomes.
How similar studies have performed: Other studies have explored similar factors in dental implants, but this specific comparison of connection types is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * One missing tooth in the premolar or molar area with both opposing and adjacent teeth (mesial and distal). Exclusion Criteria: * One-stage bone augmentation. * Uncontrolled type 1 or 2 diabetes (HgA1c\>8). * Known auto-immune or inflammatory disease. * Severe hematologic disorders, such as hemophilia or leukemia. * Local or systemic infection that may compromise normal healing (e.g., extensive periapical pathology). * Liver or kidney dysfunction/failure. * Currently receiving cancer treatment or within 18 months from completion of radio- or chemotherapy. * Long-term history of oral bisphosphonates use (i.e., 10 years or more). * History of intravenous bisphosphonates. * Long-term (\>3 months) history of antibiotics or drugs known to alter the inflammation and/or immunological system 3 months before inclusion. * Severe osseous diseases (e.g., Paget disease of bone). * Pregnant women or nursing mothers. * Not able or not willing to follow instructions related to the study procedures.
Where this trial is running
Granada
- Universidad de Granada — Granada, Spain (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.