Evaluating bone healing in sinus augmentation using different graft materials
Official title: Sinus Augmentation Healing With Autogenous and Xenograft Mix Compared to Xenograft Alone
Run by Tufts University · NCT06247098 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether using a mix of your own bone and a different type of bone graft helps people heal better after a sinus lift surgery compared to using just the graft alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | Tufts University Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT06247098 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 to 100 with less than 5mm of residual bone height in need of sinus augmentation for dental implants.
✕Probably not a fit
Patients with conditions affecting bone metabolism, such as osteoporosis, or those with a history of chemotherapy or head and neck radiation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to assess bone healing four months after lateral sinus augmentation using a combination of autologous bone and xenograft compared to xenograft alone. The evaluation will include radiographic volumetric measurements, histomorphometric analysis, and histologic examination to determine the effectiveness of the different grafting techniques. Patients will undergo sinus lift augmentation procedures, and their outcomes will be monitored using cone-beam computed tomography systems. The study is conducted at Tufts University School of Dental Medicine.
Why it matters
Potential benefit: If successful, this study could improve the outcomes of sinus augmentation procedures, leading to better dental implant success rates for patients.
How similar studies have gone: Previous studies have shown varying success with different grafting techniques in sinus augmentation, but this specific comparison of autograft and xenograft has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients of Tufts School of Dental Medicine (TUSDM) * Two stage sinus augmentations with \<5mm (Zinner, Small 2004) residual bone height in need of augmentation for implant placement * Full maxillary edentulism or Kennedy class I or III * 18 to 100 year old Exclusion Criteria: * Adults unable to consent (cognitively impaired adults) * Those who self-report as pregnant or breastfeeding * Wards of the state * Non-Viable neonates * Neonates of uncertain viability * \< 18 years of age * Refusal to participate * Prior medical condition causing complications in bone metabolism * Osteoporosis * History of/or current chemotherapy * History of/or current head and neck radiation * Current heavy smoking \> 10 cigarettes/day * Self-reported pregnancy or lactation * Previous history of sinus elevation procedure * Existing sinus pathology or pathology discovered at time of sinus augmentation or implant placement * Absence of autogenous donor site
Where it's running
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Tufts University School of Dental Medicine
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Lorenzo Mordini, DDS, MS — Tufts Univeristy
- Study coordinator: Lorenzo Mordini, DDS, MS
- Email: lorenzo.mordini@tufts.edu
- Phone: 6176366888
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.