Evaluating biomarkers to predict recovery after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the predictive power of various clinical, neurophysiological, and neuroimaging biomarkers on motor functional recovery and disability following a stroke. Patients with ischemic or hemorrhagic strokes and hemiparesis will undergo a comprehensive multimodal assessment at multiple time points post-stroke. The study will analyze data to construct an integrated biomarker algorithm that can effectively predict individual recovery outcomes, focusing on changes in motor function as measured by the Fugl-Meyer score and other relevant assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* First stroke in the middle cerebral artery territory.
* Ischemic or hemorrhagic stroke (7-30 days post-acute event).
* Upper limb plegia or paresis.
* Both genders, aged \>18 years.
* Ability to provide informed consent by the patient or caregiver/responsible relative.

Exclusion Criteria:

* Previous stroke.
* Stroke in territories other than the middle cerebral artery.
* Inability to provide informed consent.
* Contraindications to TMS or MRI.
* History of cancer in the past two years.
* Presence of other neurological conditions interfering with biomarkers

Where it's running

• IRCCS San Raffaele
  Roma, Italy, Italy Recruiting

Study contacts

• Study coordinator: Domenica Le Pera, MD, PhD
• Email: domenica.lepera@sanraffaele.it
• Phone: +390652252344

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Stem cell therapy for chronic stroke recovery

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• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

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• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

  This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

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• Remote Ischaemic Conditioning for Fatigue After Stroke 2

  Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.