Evaluating biomarkers for treating Anorexia Nervosa

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the levels of Growth Differentiation Factor-15 (GDF-15) and inflammatory cytokines in patients diagnosed with restrictive Anorexia Nervosa, both exercising and non-exercising subtypes. By comparing these levels in patients to those in healthy controls, the study seeks to identify potential biological targets for treatment. Additionally, body composition and energy expenditure will be measured to correlate these biomarkers with physical health metrics. The findings may pave the way for more individualized treatment approaches for Anorexia Nervosa.

Why it matters

Who can join: the full rules

N=8 adult male and female patients with confirmed diagnosis of anorexia nervosa restrictive type, non-exercising subtype

Inclusion criteria:

* Age 18-60 years
* Written informed consent
* BMI 10-16 kg/m2

N=8 adult male and female patients with confirmed diagnosis of anorexia nervosa restrictive type, exercising subtype will be included in this study.

Inclusion criteria:

* Age 18-60 years
* Written informed consent
* BMI 10-16 kg/m2

N=16 control participants, sex- and age-matched to the individual anorexia nervosa patients.

Inclusion criteria:

* Age 18-60 years
* Written informed consent
* BMI 19-24.9 kg/m2

Exclusion Criteria:

* Use of antibiotics within the last 31 days
* Current illicit drug abuse including daily marijuana or CBD (cannabidiol) consumption (≤ 24 g of alcohol per day allowed)
* Any kind of severe chronic disease other than AN (e.g. active cancer disease)
* Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2) if resulting from another disease than AN
* Known liver cirrhosis or other severe liver impairment if resulting from another disease than AN
* Acute upper respiratory tract infection within the last 31 days
* Uncontrolled dysthyroidism
* Uncontrolled hypertension
* Current pregnancy/lactation or current treatment for in vitro fertilization
* Inability to understand the study information, to sign the consent form and to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.

Where it's running

• University Hospital Basel
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Katharina Timper, Prof. — University Hospital, Basel, Switzerland
• Study coordinator: Katharina Timper, Prof.
• Email: katharina.timper@usb.ch
• Phone: +41613285742

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.