Evaluating biomarkers for the outcome of pulpotomy in molars with irreversible pulpitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to recruit 180 molars diagnosed with irreversible pulpitis to assess the outcomes of full pulpotomy compared to root canal treatment. A total of 120 teeth will undergo pulpotomy, while 60 will receive root canal treatment as a control. Blood samples and pulp tissues will be collected for analysis to profile inflammation-related biomarkers. The treatment outcomes will be evaluated clinically and radiographically at 6 and 12 months post-treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Permanent molars showing clinical and radiographic evidence of a deep carious lesion (extend to the three-quarters thickness of dentine radiographically) extending close to the pulp chamber
* Clinical diagnosis of irreversible pulpitis, including spontaneous pain, lingering pain with cold stimulation, no or mild tenderness to percussion, normal apical tissue or widening of the periodontal ligament space but with no signs of periapical periodontitis (i.e., PAI score 1 or 2)
* Positive response to cold and electric pulp test.

Exclusion Criteria:

* Tooth with no response to the cold and electric tests, presence of apical radiolucency (greater than periodontal widening), signs of canal calcification and resorption, history of trauma, unrestorable or nonfunctional teeth, and evidence of perio-endo lesion
* Intraoperative bleeding time is more than 10 minutes or less than 10 μL pulpal blood can be obtained
* Patients with a compromised immune status (such as HIV or organ transplant) or with any history of taking analgesics/antibiotics in the past one week.

Where it's running

• Clinical Research Centre, Faculty of Dentistry, The University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Chengfei Zhang — The University of Hong Kong
• Study coordinator: Rong Cen
• Email: cenrong@hku.hk
• Phone: +852 28590290

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• E-IodoCal paste vs ZOE in primary molar pulpectomies

  This randomized split-mouth trial tests whether E-IodoCal paste works as well as ZOE paste for filling root canals in primary molars of children aged 4 to 8.

  Recruiting Tanta University · Tanta · NCT07883200

• Comparison of two ways to numb a child's jaw during a root canal in the back teeth

  This study tests whether digital anesthesia works as well as the traditional nerve block for numbing kids' lower back teeth during emergency root canals.

  Recruiting Inonu University · Malatya, Malatya · NCT07634900

• Pulpotomy versus root canal for painful lower premolars and molars

  This study will see if total pulpotomy, radicular pulpotomy, or root canal treatment best controls postoperative pain and leads to successful outcomes for people aged 15–45 with symptomatic irreversible pulpitis in mandibular premolars and molars.

  Recruiting Mustafa Kemal University · Hatay, Antakya · NCT07375576

• Using pre-operative findings and AI to predict whether full pulpotomy will succeed in painful mature molars

  We will test whether pre-surgery clinical signs and an AI read of dental X-rays can predict if full pulpotomy will work for adults with irreversible pulpitis in mature molars.

  Recruiting at 2 sites Misr International University · Cairo and 1 other locations · NCT07340606

• Menstrual phase and how well lower-jaw dental anesthesia works

  This research will test whether different menstrual cycle phases change how well an inferior alveolar nerve block works for women (20–40) with painful irreversible pulpitis in lower molars.

  Recruiting Jamia Millia Islamia · New Delhi, Delhi(दिल्ली) · NCT07306533

• How French dentists treat infected or non-vital baby (primary) teeth

  See how dentists in France treat children’s non-vital or infected primary teeth and what leads them to choose extraction, pulpectomy, or other options.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07297836

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.