Evaluating biomarkers for pneumonia in ventilated patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess various peptide biomarkers, microbiome variations, and bacterial transcriptome patterns to identify prognostic and diagnostic indicators for ventilator-associated pneumonia (VAP). Patients admitted to intensive care units who have been intubated within the last 24 hours and are expected to be mechanically ventilated for at least 48 hours will be monitored. The study will analyze the relationship between these biomarkers and the development of VAP, potentially leading to improved diagnostic methods. The research will involve collaboration between multiple hospitals and institutions to gather comprehensive data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Admission to an intensive care unit
* Intubation within last 24 hours
* Anticipated mechanical ventilation of at least 48 hours

Exclusion Criteria:

* FiO2 above 70% or PEEP above 15
* Severe coagulopathy (spontaneous PK(INR) \>1.8 or thrombocytes \<50). Prophylaxis treatment dose of LMWH or factor Xa inhibitors/NOAC is not an exclusion criteria. If higher doses of these substances are administered, the responsible clinician should be consulted before sample collection.
* Ongoing infection of the lungs at admission to the ICU.
* Severely elevated or instable intracranial pressure.

Where it's running

• Vestre Viken
  Drammen, Norway Recruiting
• Hospital de São Francisco Xavier
  Lisbon, Portugal Recruiting
• Skåne University Hospital, Dept. of Infectious diseases
  Lund, Sweden Recruiting
• Skåne university Hospital, ICU
  Malmö, Sweden Recruiting
• Karolinska University Hospital, ICU
  Solna, Sweden Not yet recruiting

Study contacts

• Principal investigator: Magnus Paulsson, PhD MD — Skane University Hospital
• Study coordinator: Magnus Paulsson, PhD MD
• Email: magnus.paulsson@med.lu.se
• Phone: +46461775431

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.