Evaluating bicalutamide and sunitinib for advanced kidney cancer

A Phase I/II Study to Evaluate the Safety and Efficacy of Bicalutamide in Combination With Sunitinib in Patients With Receptor Tyrosine Kinase Inhibitor Resistant Renal Cell Carcinoma

This study is testing if a combination of two medications, bicalutamide and sunitinib, can help people with advanced kidney cancer who have not responded to previous treatments.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 28 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: State University of New York at Buffalo (Academic / other)
• Drugs / interventions: sunitinib
• Locations: 1 site (Buffalo, New York)
• Trial ID: NCT06222593 on ClinicalTrials.gov

What this trial studies

This Phase I/II open-label study investigates the safety and efficacy of bicalutamide combined with sunitinib in patients with advanced renal cell carcinoma (RCC) who have previously been treated with receptor tyrosine kinase inhibitors and experienced disease progression. Patients will receive sunitinib on a schedule of two weeks on and one week off, while bicalutamide will be administered orally at a daily dose of 50 mg. The study employs Simon's optimal two-stage design to assess treatment response, with a total of 16 patients to be enrolled if initial responses are observed.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with measurable advanced renal cell carcinoma who have previously progressed on receptor tyrosine kinase inhibitors.

Not a fit: Patients who have not been treated with receptor tyrosine kinase inhibitors or those with other types of cancer may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment combination could provide a new therapeutic option for patients with advanced RCC who have limited treatment alternatives.

How similar studies have performed: While this specific combination has not been extensively tested, similar approaches in targeting advanced RCC have shown promise in other studies.

Eligibility criteria

Inclusion Criteria:

1. Be willing and able to provide written informed consent for the trial.
2. Be greater than or equal to 18 years of age on day of signing informed consent.
3. Have measurable disease based on RECIST 1.1
4. Have a performance status of 0-2 on the Eastern Cooperative Oncology Group (ECOG) Performance Scale
5. Demonstrate adequate organ function
6. Female subject of childbearing potential should have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medication.
7. Subjects of childbearing potential should be willing to use 2 methods of contraception for the course of the study through 120 days after the last dose of study medication
8. Male subjects without a previous vasectomy should agree to use an adequate method of contraception (i.e. abstinence, condom with spermicidal foam/gel/film/cream) starting with the first dose of study therapy through 120 days after the last dose of study therapy.
9. Subjects have archival tumor tissue available or are willing to undergo a baseline biopsy prior to treatment.
10. Subjects must have a life expectancy of at least 6 months.

Exclusion Criteria:

1. Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment.
2. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment.
3. Has active Bacillus tuberculosis (TB)
4. Has a known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer.
5. Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
6. Has an active infection requiring systemic therapy.
7. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.
8. Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
9. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through 120 days after the last dose of trial treatment.
10. Has a known history of Human Immunodeficiency Virus (HIV)
11. Has known active Hepatitis B or Hepatitis C
12. Has received a live vaccine within 30 days of planned start of study therapy

Where this trial is running

Buffalo, New York

• UB/ Great Lakes Cancer Care — Buffalo, New York, United States (Recruiting)

Study contacts

• Principal investigator: Roberto Pili, MD — State University of New York at Buffalo
• Study coordinator: Roberto Pili, MD/PhD

Conditions Carcinoma, Renal Cell