Evaluating balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension in China

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the safety and efficacy of balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are not suitable for pulmonary endarterectomy or have persistent CTEPH after the procedure. The study involves a multi-center approach, where clinical evaluations such as functional capacity tests, biomarkers, and imaging studies will be conducted before and after BPA treatment. Additionally, the study will explore the predictive value of FAPI in determining treatment efficacy and patient prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. diagnosed with CTEPH according to ESC Guidelines (1) Mean PAP ≥ 25mmHg at rest; or if mean PAP \< 25mmHg at rest, have exercise limitations from chronic thromboembolic disease (2)Abnormal ventilation perfusion lung scanning (VQ) scan, pulmonary angiogram, computer tomographic pulmonary angiogram, or magnetic resonance pulmonary angiogram confirming chronic thromboembolic disease as recommended by standard guidelines
2. Treatment with anticoagulation for ≥ 3 months before diagnosis of CTEPH
3. Not amenable to pulmonary endarterectomy
4. Willing to provide informed consent

Exclusion Criteria:

1. Patients unwilling or unable to provide written consent for participation in the study.
2. Impossible to follow up.

Where it's running

• center of pulmonary vascular disease, Fuwai hospital
  Beijing, China Recruiting
• Chinese Academy of Medical Sciences Fuwai hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Zhihong Liu, doctor
• Email: zhihongliufuwai@163.com
• Phone: 8601088396985

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.