Evaluating autologous blood transfusion in spinal surgery for lung cancer with spinal metastasis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess the safety and efficacy of autologous blood transfusion during spinal surgery for patients with lung cancer spinal metastases. Participants will be randomly assigned to receive either autologous or allogeneic blood transfusions during standard open spinal decompression surgery. The study will measure various outcomes, including the incidence of new metastases, postoperative hemoglobin levels, circulating tumor cells, and the rate of allogeneic transfusions. Advanced techniques such as flow cytometry and immunohistochemistry will be employed to analyze blood samples before and after transfusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The age range is 18-75 years old;
* The pathological diagnosis was lung cancer and spinal metastatic tumor;
* Expected survival \> 3 months, can tolerate surgery;
* Unstable spine; And/or spinal cord nerve compression, nerve function; Progressive decline, palliative spinal open decompression surgery
* Patients with intraoperative/postoperative Hb\<90 g/L or other conditions requiring blood transfusion

Exclusion Criteria:

* Serious heart dysfunction or heart failure, diagnosed blood system diseases, coagulation disorders;
* Severe renal insufficiency or need hemodialysis treatment;
* Sepsis or septicemia;
* Unable to obtain consent from the patient or family.

Where it's running

• Guangdong provincial people's hospital
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Yu Zhang, Ph.D.
• Email: luck_2001@126.com
• Phone: 8613602744495

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.