Evaluating anesthetics' effects on high-dose rocuronium during laparoscopic surgery
Effects of Sevoflurane, Desflurane or Propofol Anesthesia on High-Dose Rocuronium in Laparoscopic Cholecystectomy Operations
This study tests how different anesthetics affect the muscle relaxation from a medication used during laparoscopic surgery to see which one helps patients recover better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Mustafa Kemal University Academic / other |
| Locations | 1 site (Antakya, Hatay) |
| Trial ID | NCT06045559 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how three different anesthetics—propofol, desflurane, and sevoflurane—affect the duration of neuromuscular blockade induced by high doses of rocuronium in patients undergoing laparoscopic cholecystectomy. Patients are randomly assigned to one of the anesthetic groups, and their neuromuscular function is monitored using Train of Four (TOF) and bispectral index (BIS) during surgery. The study aims to determine the optimal anesthetic that enhances the effects of rocuronium while potentially reducing intra-abdominal pressure and postoperative complications. The findings could provide insights into improving surgical outcomes and patient recovery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-65 with an ASA classification of I-III who are undergoing laparoscopic cholecystectomy.
Not a fit: Patients with rocuronium or sugammadex allergies, those with significant comorbidities, or individuals outside the age range may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthesia protocols that enhance surgical conditions and reduce postoperative complications.
How similar studies have performed: Previous studies have indicated that deep neuromuscular blockade can improve surgical outcomes, suggesting that this approach may yield beneficial results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiology (ASA) Ⅰ-Ⅲ patients * between the ages of 18-65 Exclusion Criteria: * Being under 18 of age or over 65 * disapproval of the informed consent * rocuronium allergy * sugammadex allergy * pregnancy * lactation * hepatic or renal dysfunction * obesity (BMI≥35kg/m2) * Previous abdominal surgery * long-term use of NSAIs * neuromuscular disorders
Where this trial is running
Antakya, Hatay
- Hatay Mustafa Kemal University — Antakya, Hatay, Turkey (Recruiting)
Study contacts
- Principal investigator: Selim Turhanoglu, MD — Mustafa Kemal University
- Study coordinator: Selim Turhanoglu, MD
- Email: adat63@gmail.com
- Phone: +905325062988
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.