Clinical trial Recruiting at 1 site Observational Ages 2 to 100

Evaluating and treating eye diseases

Official title: Studies of the Natural History, Pathogenesis and Outcome of Ocular Disorders

Run by National Institutes of Health Clinical Center (CC) · NCT02821767 · Data updated 2026-11-12

This study is testing standard treatments for different eye diseases in people to see how well they work and to gather information for future research.

Quick facts

Study typeObservational
Ages2 Years to 100 Years
SexAll
Enrollment1000 (estimated)
SponsorNational Institutes of Health Clinical Center (CC)
NIH
Locations1 site (Bethesda, Maryland)
StatusRecruiting
StartedAugust 3, 2016
Main results expectedJuly 1, 2027
Study endsJuly 1, 2027
Registry record updatedOctober 13, 2026
Trial IDNCT02821767 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals with diagnosed, undiagnosed, or suspected eye diseases who can provide informed consent.

Probably not a fit

Patients with systemic diseases that hinder adequate ophthalmologic examination or treatment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The National Eye Institute (NEI) is conducting an observational study to evaluate and provide standard treatment for individuals with various eye diseases. Participants will undergo a series of eye exams and assessments over a period of up to five years, with visits ranging from one to twelve times per year based on their specific condition. The study aims to collect data and specimens to enhance understanding of eye diseases, their inheritance, and the effectiveness of standard treatments. Additionally, it seeks to establish a resource for future research on ocular conditions.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and treatment options for patients with eye diseases.

How similar studies have gone: Other studies focusing on the natural history and treatment of ocular diseases have shown promise, indicating that this approach is supported by previous findings.

Who can join: the full rules

Show full inclusion / exclusion criteria
* INCLUSION CRITERIA:

To be eligible, the following inclusion criteria must be met, where applicable.

1. Have a diagnosed, undiagnosed or suspected eye disease.
2. Have the ability to understand and sign an informed consent or have a parent/legal guardian do so if they are minor children or a legally authorized representative (LAR) to provide consent for adults without consent capacity.

EXCLUSION CRITERIA:

A participant is not eligible if any of the following exclusion criteria are present.

1. Are unwilling to give informed consent or assent when applicable.
2. Are unwilling or unable to be followed as clinically indicated.
3. Have a systemic disease that compromises the ability of NEI clinicians to provide adequate ophthalmologic examination or treatment.

Where it's running

  • National Institutes of Health Clinical Center
    Bethesda, Maryland, United States
    Recruiting

Study contacts

  • Principal investigator: Awilda V Holland, R.N. — National Eye Institute (NEI)
  • Study coordinator: Awilda V Holland, R.N.
  • Email: aholland@nei.nih.gov
  • Phone: (301) 435-1831

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.