Evaluating and managing heart disease risk in cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

REDEEM-CAD is a prospective multi-centre study focused on assessing the risk of coronary artery disease (CAD) in cancer survivors aged 40-70 who received chemotherapy or radiotherapy more than five years ago. The study employs a novel clinical and imaging-based screening algorithm to identify individuals at high risk for developing CAD. Participants will undergo follow-up assessments over an average of 36 months, with clinic reviews at 12, 24, and 36 months to monitor their health and manage risk factors effectively. The findings will be compared to data from two existing studies to evaluate the prevalence of subclinical CAD and the efficacy of the screening and management plan.

Why it matters

Who can join: the full rules

Inclusion Criteria:

A history of cancer \>5 y ago associated with potential cardiotoxicity from chemotherapy and/or radiotherapy (chiefly survivors of breast cancer, Hodgkin's lymphoma and prostate cancer).

Exclusion Criteria:

* Unable to provide written informed consent to participate in this study
* Known coronary artery disease at recruitment
* History of previous coronary artery disease
* Inability to acquire interpretable CT images
* Contraindications/Intolerance to or already taking statin therapy
* Oncologic (or other) life expectancy \<12 months or any other medical condition (including pregnancy) that results in the belief (deemed by the Chief Investigators) that it is not appropriate for the patient to participate in this trial

Where it's running

• Tom Marwick
  Hobart, Tasmania, Australia Recruiting
• Baker Heart and Diabetes Institute
  Melbourne, Victoria, Australia Recruiting

Study contacts

• Principal investigator: Tom Marwick, MBBS,PhD,MPH — Baker Heart and Diabetes Institute
• Study coordinator: Tom Marwick, MBBS,PhD,MPH
• Email: tom.marwick@baker.edu.au
• Phone: +61 3 8532 1550

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.