Evaluating adverse drug reactions in patients taking multiple medications

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the impact of polypharmacy on adverse drug reactions (ADRs) in at-risk patients using advanced pharmacogenomic technology. The study will analyze data from a pilot cohort to optimize pharmacotherapy regimens and develop a clinical decision support dashboard to identify necessary modifications in drug regimens. Additionally, it will evaluate the capacity of CYP P450 enzymatic pathways in patients on multiple medications and assess the feasibility of integrating informatics workflows between the laboratory and clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* People taking 5 or more medications, including over the counter drugs, supplements, natural products, cannabis produces, or other recreational drugs
* Ability to give and comprehend the consent process.
* Consent to donate urine samples, genetic data through buccal swabs, undergo a comprehensive history and physical examination.
* All genders.
* Age 45 and over

Exclusion Criteria:

* Subject has been diagnosed or is being treated for any cancer other than basal cell cancer in the last 5 years. Patients with metastatic melanoma in the last 5 years will be excluded.
* Admitted to hospice.
* Patient has ever been diagnosed with Hepatitis B or C.
* Patient has ever been diagnosed with active liver disease, hepatomegaly, grossly abnormal liver function. Meld score \>10, ALT or AST \>100U/L or an AST/ALT ratio \>2
* Patients taking imidazole antifungal medication.
* Declines to participate or interact with staff/share their medical status.
* A diagnosis of Alzheimer's disease
* Pregnant patients will be excluded
* Unable/unwilling to consent.
* Unable to verbally communicate and comprehend English/Spanish language.

Where it's running

• The Interprofessional Pharmacogenomics (IPGx) Clinic
  Bryan, Texas, United States Recruiting

Study contacts

• Principal investigator: Kenneth S Ramos, MD — Texas A&M IBT
• Study coordinator: Kenneth S Ramos, MD
• Email: kramos@tamu.edu
• Phone: 7136777740

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.