Evaluating adenoma detection rates in colonoscopy
Improving Colonoscopy Adenoma Detection Metrics by Extending the Screening-only Measurement to All Indications: a Prospective Multicenter Study
This study is testing if the overall rate of finding polyps during colonoscopy can be a good alternative measure for screening in people aged 50 and older.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2700 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | Evergreen General Hospital, Taiwan Academic / other |
| Locations | 6 sites (North Hills, California and 5 other locations) |
| Trial ID | NCT05125939 on ClinicalTrials.gov |
What this trial studies
This multicenter observational study aims to assess whether the overall adenoma detection rate (ADR) can serve as a reliable alternative to the screening ADR in colonoscopy procedures. Conducted by 18 colonoscopists across 5 hospitals in Taiwan, the study plans to enroll 2700 participants aged 50 and older over a two-year period. It will categorize colonoscopy indications into screening, surveillance, diagnostic, and positive fecal immunochemical test (FIT+), and compare ADR across these categories. The study will also explore the correlation between screening ADR and overall ADRs, both including and excluding FIT cases.
Who should consider this trial
Good fit: Ideal candidates are consecutive patients aged 50 years and older who are undergoing colonoscopy.
Not a fit: Patients with a high risk family history of colorectal cancer, inflammatory bowel disease, or other specified conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the effectiveness of colonoscopy screenings by providing a more reliable measure for adenoma detection.
How similar studies have performed: While similar studies have explored adenoma detection rates, this specific approach of comparing overall ADR to screening ADR is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * consecutive patients aged ≥50 years undergoing colonoscopy are eligible for enrollment. Exclusion Criteria: * high risk family history of colorectal cancer (CRC) e.g., familial adenomatous polyposis, hereditary non-polyposis CRC syndrome, multiple first degree relatives with CRC, or a single first degree relative with CRC at \<60 years * serrated polyposis syndrome * inflammatory bowel disease * colonoscopy to remove a large neoplastic polyps * obstructive lesions of the colon * gastrointestinal bleeding * current participation in other studies * hospitalized patients * mental retardation * pregnancy * refusal to provide a written informed consent.
Where this trial is running
North Hills, California and 5 other locations
- Sepulveda Ambulatory Care Center, VAGLAHS — North Hills, California, United States (Active_not_recruiting)
- E-Da Dachang Hospital — Kaohsiung City, Taiwan (Not_yet_recruiting)
- E-Da Hospital — Kaohsiung City, Taiwan (Not_yet_recruiting)
- Keelung Chang Gung Memorial Hospital — Keelung, Taiwan (Not_yet_recruiting)
- Evergreen General Hospital — Taoyuan, Taiwan (Recruiting)
- Linkou Chang Gung Memorial Hospital — Taoyuan, Taiwan (Not_yet_recruiting)
Study contacts
- Principal investigator: Chi-Liang Cheng — Evergreen General Hospital, Taoyuan, Taiwan
- Study coordinator: Chi-Liang Cheng
- Email: chiliang.cheng@gmail.com
- Phone: 0919768058
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.