Evaluating ablation therapy for lung cancer with ground-glass nodules

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial is a prospective, two-center, single-arm Phase II study aimed at assessing the safety and effectiveness of ablation therapy for patients with lung cancer presenting as ground-glass nodules. Participants will be individuals aged 18 to 85 years who have been diagnosed with ground-glass opacities (GGOs) that have not improved after three months. The study will focus on patients who are unable to undergo traditional surgical procedures due to various reasons, including the presence of multiple nodules or previous surgeries. The primary goal is to determine how well ablation therapy can manage these specific lung cancer cases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged between 18 and 85 years;
2. GGO is diagnosed by lung CT and failure to subside after 3 months (the patient having been re-examined by thin-section CT);
3. The maximum diameter of the GGO is bigger than 8mm and smaller than 3cm;
4. For single GGO: obvious progress was observed in pure GGO or the solid component of mixed ground glass nodules was more than or equal to 2 mm
5. The patients were unable to tolerate the operation for various reasons or multiple grinding glass nodules, operation can not be completely removed; or patients had received surgery in ipsilateral chest
6. The patient is able to understand and comply with the study and has provided written informed consent

Exclusion Criteria:

1. Patients who participated in any drug and / or medical device clinical trials within one month before the trial
2. had severe disease conditions
3. allergy to narcotic drugs
4. had other autoimmune disease
5. dementia or cognitive impairment can't cooperate with researchers
6. any local treatment other than ablation was received within 4 weeks before the study

Where it's running

• Department of Thoracic Surgery, Zhongshan Hospital, Fudan University
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Qun Wang, Phd
• Email: 13301050210@fudan.edu.cn
• Phone: 86-21-64041990

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.