Evaluating a tool for predicting residual neuromuscular block in surgical patients
Official title: Residual Paralysis in the Post Anesthesia Care Unit: The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. A Prospective Single-Center Open-Label Cohort Study
Run by Assiut University · NCT06899048 · Data updated 2026-11-12
This study is testing a new tool to see if it can help doctors predict leftover muscle weakness in surgical patients after they wake up from anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 91 (estimated) |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut) |
| Status | Recruiting |
| Started | August 1, 2024 |
| Main results expected | January 1, 2027 |
| Study ends | February 1, 2027 |
| Registry record updated | October 30, 2026 |
| Trial ID | NCT06899048 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 to 65 years who are classified as ASA physical status 1 or 2 and undergoing surgery requiring neuromuscular blocking agents.
✕Probably not a fit
Patients outside the age range of 18 to 65, those with neuromuscular diseases, or individuals who are pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the association between a residual neuromuscular block risk prediction score (REPS) and the Train-of-Four ratio (TOFr) in surgical patients during the early postoperative phase. The TOFr will be measured at intervals of 0, 15, 30, 45, and 60 minutes after extubation to evaluate the predictive accuracy of REPS as a tool for identifying residual neuromuscular block. By comparing these two assessment methods, the study seeks to improve postoperative monitoring and patient safety.
Why it matters
Potential benefit: If successful, this study could enhance the accuracy of predicting residual neuromuscular block, leading to improved patient outcomes in the postoperative setting.
How similar studies have gone: While the specific predictive tool being evaluated may be novel, similar studies have explored the use of quantitative assessments for neuromuscular block with varying degrees of success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age group 18-65 years old 2. Both genders 3. Patients with American Society of Anesthesiologist physical status classification of 1 or 2. Exclusion Criteria: 1. Patients who are less than 18 years old or more than 65 years old. 2. Patients with planned scheduled recovery in the intensive care unit or if more than 10 minutes had elapsed since tracheal extubation until NMB monitoring at the PACU. 3. Patients on medications that interfere with muscle activity. 4. Known allergy to neuromuscular blocking agents. 5. Pregnancy or suspected pregnancy. 6. Neuro-muscular diseases. 7. Patients refusing to participate in the study.
Where it's running
-
Assiut University Hospitals
Asyut, Egypt Recruiting
Study contacts
- Study coordinator: Mahmoud A Faisal, Dr
- Email: dr_mahmoudfaisal@aun.edu.eg
- Phone: 01004391577
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Oral Gabapentin vs IV Neostigmine/Atropine vs Both for Preventing PDPH
This study tests whether taking gabapentin by mouth, getting neostigmine with atropine by IV, or using both can help prevent postdural puncture headache after spinal anesthesia in pregnant patients.
-
Predicting Heart Muscle Recovery After CTO Revascularization
This study looks at whether blood tests and stress echo measurements can predict which patients with CTO will regain heart muscle function after a revascularization procedure.
-
Lower-dose induction for pediatric AML with G-CSF support
This study tests a lower-dose induction regimen with G-CSF in children with de novo acute myeloid leukemia to see if it lowers early toxicity without hurting survival.
-
Change in Fat Content of Bone Metastases After Treatment
This study tests if a special MRI method can see early changes in bone metastases by measuring fat content before and after chemotherapy or radiotherapy in adults.
-
Health education to see if primigravida women choose vaginal delivery more often
A health education program is being tested to see if it helps first-time pregnant women in choosing vaginal delivery over unnecessary cesareans.
-
Low-volume vs standard-volume ultrasound-guided bilateral intermediate cervical plexus block for thyroidectomy pain
This study tests whether using a smaller amount of local anesthetic on both sides before thyroidectomy can provide good pain relief while better preserving breathing.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.