Evaluating a tool for predicting residual neuromuscular block in surgical patients

Residual Paralysis in the Post Anesthesia Care Unit: The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. A Prospective Single-Center Open-Label Cohort Study

This study is testing a new tool to see if it can help doctors predict leftover muscle weakness in surgical patients after they wake up from anesthesia.

Quick facts

• Study type: Observational
• Enrollment: 91 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: Assiut University (Academic / other)
• Locations: 1 site (Asyut)
• Trial ID: NCT06899048 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the association between a residual neuromuscular block risk prediction score (REPS) and the Train-of-Four ratio (TOFr) in surgical patients during the early postoperative phase. The TOFr will be measured at intervals of 0, 15, 30, 45, and 60 minutes after extubation to evaluate the predictive accuracy of REPS as a tool for identifying residual neuromuscular block. By comparing these two assessment methods, the study seeks to improve postoperative monitoring and patient safety.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 to 65 years who are classified as ASA physical status 1 or 2 and undergoing surgery requiring neuromuscular blocking agents.

Not a fit: Patients outside the age range of 18 to 65, those with neuromuscular diseases, or individuals who are pregnant will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance the accuracy of predicting residual neuromuscular block, leading to improved patient outcomes in the postoperative setting.

How similar studies have performed: While the specific predictive tool being evaluated may be novel, similar studies have explored the use of quantitative assessments for neuromuscular block with varying degrees of success.

Eligibility criteria

Inclusion Criteria:

1. Age group 18-65 years old
2. Both genders
3. Patients with American Society of Anesthesiologist physical status classification of 1 or 2.

Exclusion Criteria:

1. Patients who are less than 18 years old or more than 65 years old.
2. Patients with planned scheduled recovery in the intensive care unit or if more than 10 minutes had elapsed since tracheal extubation until NMB monitoring at the PACU.
3. Patients on medications that interfere with muscle activity.
4. Known allergy to neuromuscular blocking agents.
5. Pregnancy or suspected pregnancy.
6. Neuro-muscular diseases.
7. Patients refusing to participate in the study.

Where this trial is running

Asyut

• Assiut University Hospitals — Asyut, Egypt (Recruiting)

Study contacts

• Study coordinator: Mahmoud A Faisal, Dr

Conditions Muscle Relaxants