Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Evaluating a tool for predicting residual neuromuscular block in surgical patients

Official title: Residual Paralysis in the Post Anesthesia Care Unit: The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. A Prospective Single-Center Open-Label Cohort Study

Run by Assiut University · NCT06899048 · Data updated 2026-11-12

This study is testing a new tool to see if it can help doctors predict leftover muscle weakness in surgical patients after they wake up from anesthesia.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment91 (estimated)
SponsorAssiut University
Academic / other
Locations1 site (Asyut)
StatusRecruiting
StartedAugust 1, 2024
Main results expectedJanuary 1, 2027
Study endsFebruary 1, 2027
Registry record updatedOctober 30, 2026
Trial IDNCT06899048 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 to 65 years who are classified as ASA physical status 1 or 2 and undergoing surgery requiring neuromuscular blocking agents.

Probably not a fit

Patients outside the age range of 18 to 65, those with neuromuscular diseases, or individuals who are pregnant will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the association between a residual neuromuscular block risk prediction score (REPS) and the Train-of-Four ratio (TOFr) in surgical patients during the early postoperative phase. The TOFr will be measured at intervals of 0, 15, 30, 45, and 60 minutes after extubation to evaluate the predictive accuracy of REPS as a tool for identifying residual neuromuscular block. By comparing these two assessment methods, the study seeks to improve postoperative monitoring and patient safety.

Why it matters

Potential benefit: If successful, this study could enhance the accuracy of predicting residual neuromuscular block, leading to improved patient outcomes in the postoperative setting.

How similar studies have gone: While the specific predictive tool being evaluated may be novel, similar studies have explored the use of quantitative assessments for neuromuscular block with varying degrees of success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age group 18-65 years old
2. Both genders
3. Patients with American Society of Anesthesiologist physical status classification of 1 or 2.

Exclusion Criteria:

1. Patients who are less than 18 years old or more than 65 years old.
2. Patients with planned scheduled recovery in the intensive care unit or if more than 10 minutes had elapsed since tracheal extubation until NMB monitoring at the PACU.
3. Patients on medications that interfere with muscle activity.
4. Known allergy to neuromuscular blocking agents.
5. Pregnancy or suspected pregnancy.
6. Neuro-muscular diseases.
7. Patients refusing to participate in the study.

Where it's running

  • Assiut University Hospitals
    Asyut, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.