Evaluating a non-invasive test for endometrial receptivity in patients with implantation failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess the clinical utility of the non-invasive Ora test, which determines the optimal timing for embryo transfer in patients experiencing implantation failure during in vitro fertilization (IVF). The study will recruit 1000 couples, randomly assigning them to either a control group receiving preimplantation genetic testing for aneuploidy (PGT-A) or a study group undergoing the Ora test. By utilizing a blood draw instead of an invasive biopsy, the trial seeks to improve the success rates of assisted reproductive treatments. The primary focus is on couples with euploid or low-level mosaic embryos who have faced previous implantation challenges.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Experienced implantation failure with euploid or low-level mosaic (\< 30%) embryos in the past two years.
* Female age 28-45 years.
* Consent to undergo a simulated cycle for non-invasive optimal implantation window testing.
* Plan to undergo a frozen embryo transfer cycle.
* Have at least one euploid or low-level mosaic (\< 30%) frozen blastocyst.

Exclusion Criteria:

* Presence of uterine cavity abnormalities that may affect implantation, such as polyps, fibroids ≧4 cm, or hydrosalpinx
* Presence of systemic diseases that may affect reproductive techniques (e.g., autoimmune diseases)
* Body mass index (BMI) over 30 kg/m²

Where it's running

• Hanoi Hospital
  Hanoi, Vietnam Recruiting

Study contacts

• Study coordinator: Tiffany Wang
• Email: tiffany@intilabs.com
• Phone: +886 3 6581031

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.