Evaluating a new technique for treating periodontal defects

Clinical and Radiographic Evaluation of Using the Entire Papilla Preservation Technique With and Without Autogenous Bone Graft and Injectable Platelet Rich Fibrin in Treatment of Periodontal Intraosseous Defects: A Randomized Clinical Tria

This study is testing a new, less invasive method for treating gum disease in adults to see if it works better with or without added bone and growth factors.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 24 (estimated)
• Ages: 18 Years to 50 Years
• Sex: All
• Sponsor: Cairo University (Academic / other)
• Locations: 1 site (Cairo)
• Trial ID: NCT06347263 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to assess the clinical and radiographic outcomes of the Entire Papilla Preservation Technique (EPPT) in treating isolated intrabony defects in patients with stage III periodontitis. The study will compare the effectiveness of this minimally invasive technique with and without the use of autogenous bone grafts and injectable platelet-rich fibrin (I-PRF). Conducted at the Faculty of Dentistry, Cairo University, the trial will involve adult patients who meet specific inclusion criteria and will be monitored over a six-month follow-up period. The goal is to develop a cost-effective and less invasive approach to periodontal treatment.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with stage III periodontitis and specific intrabony defects.

Not a fit: Patients with ongoing drug therapies affecting periodontitis, one wall intrabony defects, or those who smoke heavily may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved healing and outcomes for patients with periodontal defects.

How similar studies have performed: While similar techniques have been explored, this specific approach using EPPT with I-PRF and autogenous bone grafts is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Patients with healthy systemic condition.
2. Adult patients (18 years old and older).
3. Patients with stage lll periodontitis, having one isolated intrabony defect with probing depth \>6mm, clinical attachment level\> 6mm and at least 4 mm intrabony component involving predominantly the interproximal area of the affected tooth.
4. Patients with full mouth plaque score\<20%.
5. Patients with full mouth bleeding score\<20%.
6. Compliance with good oral hygiene.
7. Patients accept 6-months follow-up period (cooperative patients).
8. Patients provide an informed consent.

Exclusion Criteria:

1. Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis.
2. One wall intrabony defect.
3. Defects that involve the buccal and lingual sites.
4. Smokers ˃ 10 cigarettes / day.
5. Pregnant and lactating females.

Where this trial is running

Cairo

• Faculty of dentistry, Cairo University — Cairo, Egypt (Recruiting)

Study contacts

• Principal investigator: Laila T Sedeek, Bachelor — Cairo University
• Study coordinator: Laila T Sedeek, Bachelor

Conditions Isolated Intrabony Periodontal Defects in Patients With Periodontitis; Periodontal intrabony defects; Entire papilla preservation technique; EPPT; Injectable platelet rich fibrin; I-PRF