Evaluating a new method to identify vespid venom allergy risks
Official title: Is the BAT Inhibition Able to Replace Sting Challenges?
Run by Medical University of Graz · NCT04438525 · Data updated 2026-11-12
This study is testing a new blood test to see if it can help identify people at risk for severe allergic reactions to wasp and hornet stings without having to actually sting them.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 219 (estimated) |
| Sponsor | Medical University of Graz Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (Graz) |
| Status | Recruiting |
| Started | January 7, 2021 |
| Main results expected | September 2028 |
| Study ends | December 2028 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT04438525 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 to 70 who are currently receiving or have previously received vespid venom immunotherapy.
✕Probably not a fit
Patients who are pregnant, have autoimmune diseases, or have uncontrolled cardiovascular or asthma conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates whether BAT inhibition can serve as an alternative to traditional sting challenges for assessing vespid venom allergy. It aims to identify patients at risk of severe allergic reactions without the need for live insect stings, which are currently limited to a few centers in Europe. Participants will undergo blood donation and may be subjected to sting challenges as part of the evaluation process. The goal is to improve access to testing and enhance patient safety in managing insect venom allergies.
Why it matters
Potential benefit: If successful, this approach could provide a safer and more accessible method for identifying patients at risk of severe allergic reactions to insect stings.
How similar studies have gone: While traditional sting challenges are well-established, this specific approach using BAT inhibition is novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Legally competent male and female subjects who are currently treated or who have been treated with vespid venom immunotherapy * Age ≥18 and ≤70 years * Written consent of the participant after being informed Exclusion Criteria: * Pregnancy * Autoimmune disease * Uncontrolled cardiovascular disease * Uncontrolled asthma
Where it's running
-
Department of Dermatology and Venerology, Medical University of Graz
Graz, Austria Recruiting
Study contacts
- Study coordinator: Gunter J Sturm, MD, PhD
- Email: gunter.sturm@medunigraz.at
- Phone: +4331638580318
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.