Evaluating a new antibody treatment for advanced triple-negative breast cancer

ISIdE: Open Label, Multicentric, Single-arm Phase IIIB Trial to Evaluate the Safety and Efficacy of Sacituzumab Govitecan in Triple Negative Metastatic Breast Cancer Patients With a Biomarker Analysis

This study is testing a new antibody treatment for people with advanced triple-negative breast cancer who haven't responded well to previous chemotherapy to see if it can help them.

Quick facts

• Phase: Phase 3
• Study type: Interventional
• Enrollment: 96 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Unicancer (Academic / other)
• Drugs / interventions: chemotherapy, immunotherapy, prednisone, Sacituzumab
• Locations: 1 site (Villejuif)
• Trial ID: NCT05552001 on ClinicalTrials.gov

What this trial studies

This European multicentric trial assesses the efficacy of Sacituzumab Govitecan in patients with locally advanced or metastatic triple-negative breast cancer who have experienced disease progression despite prior chemotherapy. The study aims to include 100 patients and will evaluate treatment efficacy in less pretreated individuals while also identifying biomarkers that may predict response or resistance to the drug. Participants will receive the treatment until disease progression, unacceptable toxicity, or withdrawal from the study.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with pathologically documented locally advanced inoperable or metastatic triple-negative breast cancer that has progressed after prior chemotherapy.

Not a fit: Patients with early-stage triple-negative breast cancer who have not yet undergone chemotherapy or those with HER2 overexpression will not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with advanced triple-negative breast cancer who have limited treatment alternatives.

How similar studies have performed: Other studies have shown promising results with similar antibody treatments in triple-negative breast cancer, indicating potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

1. Patient must have signed a written informed consent prior to any trial specific procedures;

   Note: When the patient is unable to write to give his written consent, a trusted person of their choice, independent from the investigator or the sponsor, can confirm in writing the patient's consent
2. Male or female ≥ 18 years of age;
3. Patients with pathologically documented locally advanced inoperable or metastatic triple negative breast cancer (mTNBC) whose disease has progressed on (neo)adjuvant chemotherapy+/-immunotherapy for early TNBC or within 6 months after the end of any systemic therapy, surgery or radiotherapy with curative intent, whatever comes last.

   Note: TNBC is defined as the absence of HER2 overexpression by immunohistochemistry (IHC) defined as IHC 0, 1+, or 2+ and fluorescence in situ hybridization \[FISH\] non-amplified and estrogen receptor (ER) expression \<10% and progesterone receptor (PR) expression \<10% by local pathological assessment on the most recent tissue sample collected
4. Prior exposure to a taxane

   Note: If indicated, prior therapy with ICI for patients with PD1 positive tumor and prior treatment with PARP inhibitor for patients with gBRCAm is required
5. Measurable disease, as defined by RECIST v1.1
6. Patient must have accepted to perform on-treatment biopsies. If the physician considers doing the biopsy on the primary tumor site because accessibility, it can be performed only if the primary tumor site has not been previously irradiated;
7. Have metastatic site easily accessible to biopsy (with exception of bone metastasis)

   Note 1: Patients with only bone metastasis will be eligible if the primary tumor is accessible for biopsy at inclusion

   Note 2: If the patient has a single measurable lesion and it is the only one that can be biopsied, the patient cannot be included because the disease is no longer measurable according to RECIST v1.1
8. Eastern Cooperative Oncology Group (ECOG) performance status ≤2;
9. Life expectancy ≥12 weeks;
10. Adequate haematologic and organ function
11. Negative hepatitis B surface antigen (HBsAg) test at screening (patients with a negative HBsAg test and a positive total hepatitis B core antibody (HBcAb) test at screening are eligible), negative hepatitis C virus (HCV) antibody test at screening, or positive HCV antibody test followed by a negative HCV RNA test at screening;
12. Evidence of post-menopausal status or negative pregnancy urinary test within 72 hours or serum pregnancy test within 14 days before study treatment and confirmed prior to treatment on Cycle 1 Day 1 for female pre-menopausal patients;
13. Woman of childbearing potential and male patient must agree to use adequate contraception for the duration of trial participation and up to 6 months after completing treatment for women and up to 3 months for men;
14. Patient affiliated to a social security system (or equivalent);
15. Patient is willing and able to comply with the protocol for the duration of the trial including undergoing treatment and scheduled visits, and examinations including follow-up;

Exclusion Criteria:

1. Participation in another therapeutic trial within the 30 days prior to C1D1;
2. Symptomatic, untreated, or actively progressing central nervous system (CNS) metastases or evidence of leptomeningeal disease or clinically active spinal cord compression. Patients with stable and asymptomatic brain metastases will be eligible, yet the number will be capped to 15% of the overall population;
3. Previous history of cancer other than mTNBC within 5 years prior to C1D1, except of those with a negligible risk of metastasis or death (e.g., 5-year OS rate \>90%) and treated with curative intent (e.g. carcinoma in situ of the cervix, non-melanoma skin carcinoma, localized prostate cancer, ductal carcinoma in situ, or stage I uterine cancer);
4. Prior treatment with topoisomerase-1 inhibitor or with ADC containing topoisomerase-1 inhibitor
5. Met any of the following criteria for cardiac disease:

   1. Myocardial infarction or unstable angina pectoris within 6 months of enrolment.
   2. History of serious ventricular arrhythmia (ie, ventricular tachycardia or ventricular fibrillation), high-grade atrioventricular block, or other cardiac arrhythmias requiring antiarrhythmic medications (except for atrial fibrillation that is well controlled with antiarrhythmic medication); history of QT interval prolongation.
   3. New York Heart Association (NYHA) Class III or greater congestive heart failure or left ventricular ejection fraction of \<40%.
6. Severe uncontrolled infection requiring oral or IV antibiotics within 4 weeks prior to C1D1;
7. Major surgical procedure within 4 weeks prior to C1D1;
8. History of severe allergic, anaphylactic, or other hypersensitivity reactions to humanized antibodies;
9. Known hypersensitivity to the study drug, its metabolites, or formulation excipient.
10. Patients receiving concomitant anti-cancer treatments such as chemotherapy, immunotherapy, endocrine therapy and radiotherapy;
11. Patients with unresolved toxicities from previous anticancer therapy, defined as toxicities (other than alopecia) not yet resolved according to the common terminology criteria for adverse events of the National Cancer Institute (NCI-CTCAE) v5.0 grade \>2
12. Treatment with systemic corticosteroids dosed at \>20 mg prednisone or equivalent or other systemic immunosuppressive medications within 2 weeks prior to C1D1;
13. Known history of testing positive for HIV or known acquired immunodeficiency syndrome if not controlled;
14. Evidence of significant uncontrolled concomitant disease;
15. Requirement for ongoing therapy with medications that are prohibited or to be used with caution
16. Individuals with physical or psychological conditions considered not to be compatible with the trial;
17. Persons deprived of their liberty or under protective custody or guardianship;
18. Pregnant or breastfeeding women;
19. Patients unwilling or unable to comply with the medical follow-up required by the trial because of geographic, familial, social, or psychological reasons.

Where this trial is running

Villejuif

• Gustave Roussy — Villejuif, France (Recruiting)

Study contacts

• Principal investigator: Barbara Pistilli, MD — Gustave Roussy, Cancer Campus, Grand Paris
• Study coordinator: Clara GUYONNEAU, PharmD

Conditions Triple Negative Breast Cancer; Metastatic Breast Cancer; breast cancer; metastatic; triple negative; sacituzumab govitecan; biomarker analysis