Evaluating a method to reduce blood loss in pediatric patients with central venous catheters
SISIPUSH: Evaluation of Hemolysis and Iatrogenic Anemia Using the Push-pull Method to Obtain Blood from Pediatric Patients with Central Venous Catheters
This study is testing a new way to take blood samples from children with central venous catheters to see if it can help reduce blood loss and prevent anemia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 0 Years to 18 Years |
| Sex | All |
| Sponsor | University Hospital, Ghent Academic / other |
| Locations | 1 site (Ghent) |
| Trial ID | NCT06657534 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the impact of the push-pull technique on hemolysis and iatrogenic anemia in pediatric patients who have central venous catheters. By utilizing this method, the study seeks to minimize blood loss during blood sampling, which is particularly significant in children due to their smaller blood volume. The research will involve hospitalized patients aged 0-18 years at Ghent University Hospital, focusing on those requiring regular blood collections. The goal is to improve clinical outcomes by reducing the incidence of anemia and the need for blood transfusions or iron supplements.
Who should consider this trial
Good fit: Ideal candidates for this study are hospitalized pediatric patients aged 0-18 years with a central venous catheter in place.
Not a fit: Patients with a bloodstream or catheter-related infection at the time of randomization may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of anemia in hospitalized children, leading to better recovery outcomes.
How similar studies have performed: While limited data exists on iatrogenic anemia in children, similar approaches in adult populations have shown promise, suggesting potential for success in this pediatric context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * hospitalized patient at the Specialist Pediatric Department of Ghent University Hospital * age 0-18 years * presence of a central venous catheter for diagnostic or therapeutic reasons of the type surgically placed (Hickman, port-a-cath) or non-surgically placed (vena jugularis interna, subclavia, femoralis,...) * patent catheter with possibility of infusion of fluids and collection of blood on at least one of the lumens * clinical and/or radiographic confirmation of correct central position of the catheter tip * at least one blood collection per week hospitalization expected or already planned Exclusion Criteria: * presence of a bloodstream or catheter related infection before or at the time of randomization
Where this trial is running
Ghent
- Ghent University Hospital — Ghent, Belgium (Recruiting)
Study contacts
- Study coordinator: Levi Hoste, MD, PhD
- Email: levi.hoste@uzgent.be
- Phone: +32 9 332 35 40
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.