Evaluating a heart failure treatment algorithm for patients with mitral regurgitation
In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment Algorithm
This study is testing a new treatment plan to see if it helps patients with heart failure and mitral regurgitation get better results from a procedure called MitraClip.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Inova Health Care Services Academic / other |
| Locations | 1 site (Falls Church, Virginia) |
| Trial ID | NCT06675448 on ClinicalTrials.gov |
What this trial studies
This research evaluates the Inova Heart Failure Treatment Algorithm (IHFTA) to determine its effectiveness in identifying patients with symptomatic heart failure and secondary mitral regurgitation who may benefit from MitraClip repair. Patients undergoing treatment will be tracked and their outcomes assessed over time, with regular meetings to address any challenges in implementing the protocol. The study will compare the clinical and echocardiographic characteristics of patients treated with MitraClip under the IHFTA to those from a previous trial to assess the algorithm's impact.
Who should consider this trial
Good fit: Ideal candidates include adults with symptomatic mitral regurgitation due to cardiomyopathy and reduced left ventricular ejection fraction.
Not a fit: Patients who are not symptomatic or those for whom mitral valve surgery is deemed a viable option may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the identification of patients who are most likely to benefit from MitraClip repair, leading to better treatment outcomes.
How similar studies have performed: Previous studies have shown success with similar approaches in identifying effective treatments for heart failure and mitral regurgitation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic MR (≥2+) due to cardiomyopathy of either ischemic or nonischemic etiology * Subject has been adequately treated per applicable standards, including for coronary artery disease, LV dysfunction, MR, and HF. * NYHA functional class II, III, or ambulatory IV * Local heart team has determined that MV surgery will not be offered as a treatment option even if the subject is randomized to the Control group. * LVEF ≤50%. * LVESD ≤70 mm * The primary regurgitant jet , in the opinion of the MitraClip implanting investigator, can be successfully treated by the MitraClip (if a secondary jet exists, it must be considered clinically insignificant). * Transseptal catheterization and femoral vein access is feasible per the MitraClip implanting investigator. * Age 18 y or older * Subject or guardian agrees to all provisions of the protocol * NT-proBNP≥ 1500ng/ml or BNP≥ 300ng/ml Exclusion Criteria: * Untreated clinically significant coronary artery disease requiring revascularization * CABG, PCI, or TAVR within the prior 30 d * Aortic or tricuspid valve disease requiring surgery or transcatheter intervention * COPD requiring continuous home oxygen therapy or chronic outpatient oral steroid use * Cerebrovascular accident within prior 30 d * Severe symptomatic carotid stenosis (N70% by ultrasound) * Carotid surgery or stenting within prior 30 d * ACC/AHA stage D HF * Presence of any of the following: * Estimated PASP N70 mm Hg assessed by site based on echocardiography or right heart catheterization, unless active vasodilator therapy in the catheterization laboratory is able to reduce the PVR to b3 Wood units or between 3 and 4.5 Wood units with v wave less than twice the mean of the PCWP * Hypertrophic cardiomyopathy, restrictive cardiomyopathy, constrictive pericarditis, or any other structural heart disease causing HF other than dilated cardiomyopathy of either ischemic or nonischemic etiology * Infiltrative cardiomyopathies (eg, amyloidosis, hemochromatosis, sarcoidosis) * Hemodynamic instability requiring inotropic support or mechanical heart assistance * Physical evidence of right-sided congestive HF with echocardiographic evidence of moderate or severe right ventricular dysfunction * Implant of CRT or CRT-D within the last 30 d * Mitral valve orifice area \<4.0 cm2 by site-assessed TTE * Leaflet anatomy which may preclude MitraClip implantation, proper MitraClip positioning on the leaflets, or sufficient reduction in MR by the MitraClip * Hemodynamic instability defined as persistent systolic pressure \<90 mm Hg with or without afterload reduction, cardiogenic shock, or the need for inotropic support or intra-aortic balloon pump or other hemodynamic support device * Need for emergent or urgent surgery for any reason or any planned cardiac surgery within the next 12 m * Life expectancy \<12 m due to noncardiac conditions * Investigators opinion a condition that could limit the subject's participation * Status 1 heart transplant or prior orthotopic heart transplantation * Prior mitral valve leaflet surgery or any currently implanted prosthetic mitral valve, or any prior transcatheter mitral valve procedure * Echocardiographic evidence of intracardiac mass, thrombus, or vegetation * Active endocarditis or active rheumatic heart disease or leaflets degenerated from rheumatic disease (ie, noncompliant, perforated) * Active infections requiring current antibiotic therapy * TEE is contraindicated or high risk * Known hypersensitivity or contraindication to procedural medications which cannot be adequately managed medically * Pregnant or planning pregnancy within next 12m * Currently participating in an investigational drug or another device study that has not reached its primary end point * Subject belongs to a vulnerable population or has any disorder that compromises his/her ability to give written informed consent and/or to comply with study procedures.
Where this trial is running
Falls Church, Virginia
- Inova Fairfax Medical Campus — Falls Church, Virginia, United States (Recruiting)
Study contacts
- Principal investigator: Matthew Sherwood, MD — Inova Health Care Services
- Study coordinator: Hassan Saeed
- Email: hassan.saeed@inova.org
- Phone: (703) 776-5716
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.