Evaluating a faster heart scan for coronary artery disease diagnosis
Accelerated Cardiovascular Magnetic Resonance in Coronary Artery Disease
This study is testing if a faster heart scan can better diagnose coronary artery disease in patients who are already scheduled for a more invasive heart procedure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 167 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Leicester Academic / other |
| Locations | 1 site (Leicester, Leics) |
| Trial ID | NCT05221762 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the diagnostic performance of an accelerated cardiovascular magnetic resonance (CMR) protocol compared to standard CMR scans in patients with suspected coronary artery disease. A total of 167 patients referred for invasive coronary angiography will undergo both types of scans in a randomized order before their angiography. The primary goal is to determine if the accelerated CMR protocol provides better diagnostic accuracy for identifying significant coronary disease, using invasive fractional flow reserve (FFR) as the reference standard. Secondary objectives include comparing scan durations and patient experiences between the two protocols.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are being evaluated for chest pain and referred for invasive coronary angiography.
Not a fit: Patients with recent acute coronary syndrome, severe claustrophobia, or significant contraindications to CMR will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to quicker and more accurate diagnoses for patients with coronary artery disease.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in improving diagnostic accuracy in cardiac imaging.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged ≥18 years * Referred for invasive coronary angiography for investigation of chest pain * Willing and able to give informed consent * Willing and able (in the Investigators opinion) to comply with all study requirements. * Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study. * Able to understand written English Exclusion Criteria: * Recent acute coronary syndrome (\< 6 months) * Severe claustrophobia * Absolute contraindications to CMR - those with MR conditional or safe devices will be included * Second-/third-degree atrioventricular block * Severe chronic obstructive pulmonary disease * Moderate-severe asthma * Estimated glomerular filtration rate \<30 ml/min/1.73m2 * Women who are pregnant, breast-feeding or of child-bearing potential (premenopausal women) * Contraindication to iodinated contrast * Participants who have participated in a research study involving an investigational product in the past 12 weeks * Patients unable to understand written English
Where this trial is running
Leicester, Leics
- Glenfield Hospital — Leicester, Leics, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Jayanth Arnold — University of Leicester
- Study coordinator: Jayanth Arnold
- Email: jra14@le.ac.uk
- Phone: 01162583038
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.