Evaluating a collagen supplement for joint function improvement

Randomized, Double-blind Clinical Study to Evaluate the Effect of a Food Supplement Based on Hydrolyzed Collagen on Joint Function in a Moderately Active Population.

NA · Universidad Católica San Antonio de Murcia · NCT05917925

This study is testing whether a collagen supplement can help people with knee pain feel better and improve their joint function while being moderately active.

Quick facts

PhaseNA
Study typeInterventional
Enrollment80 (estimated)
Ages18 Years to 60 Years
SexAll
SponsorUniversidad Católica San Antonio de Murcia (other)
Locations1 site (La Ñora, Murcia)
Trial IDNCT05917925 on ClinicalTrials.gov

What this trial studies

This clinical study assesses the impact of a hydrolyzed collagen-based supplement on pain, function, and quality of life in individuals who are moderately physically active and experience knee pain. The study employs a randomized, double-blind, placebo-controlled design with two parallel groups, where participants will receive either the collagen supplement or a placebo for a duration of 12 weeks. The primary focus is on alleviating exercise-associated knee pain and enhancing overall joint function.

Who should consider this trial

Good fit: Ideal candidates are individuals who exercise regularly and have experienced persistent knee pain for at least two months.

Not a fit: Patients with severe illnesses, chronic inflammatory diseases, or those currently using joint health supplements may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could significantly improve joint function and quality of life for individuals suffering from knee pain.

How similar studies have performed: Other studies have shown promising results with collagen supplementation for joint health, indicating potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Individuals who exercise regularly and meet the WHO definition of being moderately active.
* Persistent exercise-associated knee pain lasting at least 2 months prior to study inclusion.
* Knee pain score on the visual analogue pain scale of at least 30 mm, taking into account that the scale has a maximum range of 100 mm.

Exclusion Criteria:

* Individuals with severe illness.
* Subjects who are taking or have been treated within the last 7 days with glucosamine, chondroitin sulphate, collagen or hyaluronic acid injections or any dietary supplement indicated for joint health.
* Subjects with chronic inflammatory diseases affecting the musculoskeletal apparatus.
* Subjects with obesity (BMI ≥ 30 Kg/m2).
* Allergy or known hypersensitivity to any of the ingredients in the investigational product.
* Phenylketonuria.
* Treatment with narcotics, steroidal anti-inflammatory drugs or immunosuppressants. - Symptoms of extreme pain requiring high doses of analgesic therapy for a period of time longer than 2 weeks or intra-articular injection treatment.
* Individuals with diabetes.
* Pregnant women.
* Lactating women.
* Subjects who are participating in a clinical trial.
* Subjects who have participated in a clinical trial for pain in the last month.

Where this trial is running

La Ñora, Murcia

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Pain, Acute, Pain, Chronic, Knee Osteoarthritis, Knee Injuries, Hydrolyzed collagen, Post-exercise pain, Supplementation, Inflammation

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.